Roderick Y. H. Lim

TL;DR: It is shown using an indentation-type atomic force microscope (IT-AFM) that unadulterated human breast biopsies display distinct stiffness profiles, and evidence obtained from the lungs of mice with late-stage tumours shows that migration and metastatic spreading is correlated to the low stiffness of hypoxia-associated cancer cells.

TL;DR: It is found that binding interactions with the transport receptor karyopherin-β1 caused the FG domains of the human nucleoporin Nup153 to collapse into compact molecular conformations, which may play an important role in regulating nucleocytoplasmic transport.

TL;DR: Findings reveal how FG-repeat domains may simultaneously function as an entropic barrier and a selective trap in the near-field interaction zone of nuclear pore complexes; i.e., selective gate.

TL;DR: It is shown that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional integrity and raises the possibility that NPC dysfunction contributes to tau-induced neurotoxicity in AD and tauopathies.

TL;DR: This work shows selective transport of proteins across individual biomimetic nuclear pore complexes at the single-molecule level in vitro, providing a quantitative platform for studying nucleocytoplasmic transport phenomena in vitro.