M
Maurizio Moggio
Researcher at University of Milan
Publications - 174
Citations - 7298
Maurizio Moggio is an academic researcher from University of Milan. The author has contributed to research in topics: Muscle biopsy & Mitochondrial DNA. The author has an hindex of 46, co-authored 157 publications receiving 6501 citations. Previous affiliations of Maurizio Moggio include University of Brescia & Columbia University.
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Journal ArticleDOI
Distinctive patterns of microRNA expression in primary muscular disorders
Iris Eisenberg,Alal Eran,Ichizo Nishino,Maurizio Moggio,Costanza Lamperti,Anthony A. Amato,Hart G.W. Lidov,Peter B. Kang,Kathryn N. North,Stella Mitrani-Rosenbaum,Kevin M. Flanigan,Lori A. Neely,Duncan Whitney,Alan H. Beggs,Isaac S. Kohane,Louis M. Kunkel +15 more
TL;DR: In this article, the authors search for miRNAs regulated during the degenerative process of muscle to gain insight into the specific regulation of genes that are disrupted in pathological muscle conditions, including Duchenne muscular dystrophy and Miyoshi myopathy.
Journal ArticleDOI
In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
Carlo Viscomi,Emanuela Bottani,Gabriele Civiletto,Raffaele Cerutti,Maurizio Moggio,Gigliola Fagiolari,Eric A. Schon,Costanza Lamperti,Massimo Zeviani +8 more
TL;DR: It is demonstrated that double-recombinant animals overexpressing PGC-1α in skeletal muscle on a Surf1 KO background showed robust induction of mitochondrial biogenesis and increase of mitochondrial respiratory chain activities, including COX.
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Cytochrome c Oxidase subunit I microdeletion in a patient with motor neuron disease
Giacomo P. Comi,Andreina Bordoni,Sabrina Salani,Liliana Franceschina,Monica Sciacco,Alessandro Prelle,Francesco Fortunato,Massimo Zeviani,L. Napoli,Nereo Bresolin,Maurizio Moggio,C.D. Ausenda,Jan-Willem Taanman,Guglielmo Scarlato +13 more
TL;DR: An out‐of‐frame mutation of the mitochondrial DNA‐encoded subunit I of cytochrome c oxidase (COX) was discovered during investigation of a severe isolated muscle COX deficiency in a patient with motor neuron‐like degeneration, suggesting that OXPHOS impairment could play a role in the pathogenesis of some MND cases.
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Autologous transplantation of muscle-derived CD133(+) stem cells in Duchenne muscle patients
Yvan Torrente,Marzia Belicchi,C. Marchesi,Giuseppe D'Antona,Filippo Cogiamanian,Federica Pisati,M. Gavina,R. Giordano,Rossana Tonlorenzi,Gigliola Fagiolari,Costanza Lamperti,Laura Porretti,R. Lopa,Maurilio Sampaolesi,L. Vicentini,N. Grimoldi,F. Tiberio,V. Songa,P. Baratta,Alessandro Prelle,Laura Forzenigo,M. Guglieri,Orietta Pansarasa,Chiara Rinaldi,Vincent Mouly,G. S. Butler-Browne,Giacomo P. Comi,P. Biondetti,Maurizio Moggio,Sergio M. Gaini,Nino Stocchetti,Maria Grazia D'Angelo,Anna Carla Turconi,Roberto Bottinelli,Giulio Cossu,Paolo Rebulla,Nereo Bresolin +36 more
TL;DR: The safety of autologous transplantation of muscle-derived CD133+ cells in eight boys with Duchenne muscular dystrophy in a 7-month, double-blind phase I clinical trial was tested.
Journal ArticleDOI
Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1
Davide Gabellini,Giuseppe D'Antona,Maurizio Moggio,Alessandro Prelle,Chiara Zecca,Raffaella Adami,Barbara Angeletti,Barbara Angeletti,Patrizia Ciscato,Maria Antonietta Pellegrino,Roberto Bottinelli,Michael R. Green,Rossella Tupler,Rossella Tupler,Rossella Tupler +14 more
TL;DR: The results suggest that FSHD results from inappropriate overexpression of FRG1 in skeletal muscle, which leads to abnormal alternative splicing of specific pre-mRNAs.