P
Pierre-François Pradat
Researcher at University of Paris
Publications - 164
Citations - 9523
Pierre-François Pradat is an academic researcher from University of Paris. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 42, co-authored 143 publications receiving 8060 citations. Previous affiliations of Pierre-François Pradat include Ulster University & Altnagelvin Area Hospital.
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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi,Paul N. Valdmanis,Patrick A. Dion,Dan Spiegelman,Brendan J. McConkey,Christine Vande Velde,Jean-Pierre Bouchard,Lucette Lacomblez,Ksenia Pochigaeva,François Salachas,Pierre-François Pradat,William Camu,Vincent Meininger,Nicolas Dupré,Nicolas Dupré,Guy A. Rouleau +15 more
TL;DR: Findings further corroborate that TDP-43 is involved in ALS pathogenesis and reports eight missense mutations in nine individuals—six from individuals with sporadic ALS and three from those with familial ALS (FALS)—and a concurring increase of a smaller T DP-43 product.
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EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) : revised report of an EFNS task force
Peter M. Andersen,Sharon Abrahams,Gian Domenico Borasio,Mamede de Carvalho,Adriano Chiò,Philip Van Damme,Orla Hardiman,Katja Kollewe,Karen E. Morrison,Susanne Petri,Pierre-François Pradat,Vincenzo Silani,Barbara Tomik,Maria Wasner,Markus Weber +14 more
TL;DR: The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak and needs to be strengthened, according to the authors.
Journal ArticleDOI
Energy metabolism in amyotrophic lateral sclerosis.
Luc Dupuis,Luc Dupuis,Pierre-François Pradat,Albert C. Ludolph,Jean-Philippe Loeffler,Jean-Philippe Loeffler +5 more
TL;DR: In this paper, a negative contribution of defective energy metabolism to the overall pathogenic process was found in patients with amyotrophic lateral sclerosis (ALS), which is characterized by the progressive degeneration of upper and lower motor neurons.
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Guidelines for preclinical animal research in ALS/MND: A consensus meeting.
Albert C. Ludolph,Caterina Bendotti,Eran Blaugrund,Adriano Chiò,Linda Greensmith,Jean-Philippe Loeffler,Richard J. Mead,Heiko G. Niessen,Susanne Petri,Pierre-François Pradat,Wim Robberecht,Markus A. Rüegg,Birgit Schwalenstöcker,Detlev Stiller,Leonard H. van den Berg,Fernando G. Vieira,Stephan von Hörsten +16 more
TL;DR: These second and improved guidelines are dedicated to the memory of Sean F. Scott and will help to establish SOPs for translational research for other neurological diseases within the next few years.
Journal ArticleDOI
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype–phenotype correlations
Stéphanie Millecamps,François Salachas,Cécile Cazeneuve,Paul H. Gordon,Bernard Bricka,Agnès Camuzat,Lena Guillot-Noel,Odile Russaouen,Gaëlle Bruneteau,Pierre-François Pradat,Nadine Le Forestier,Nadia Vandenberghe,Véronique Danel-Brunaud,Nathalie Guy,Christel Thauvin-Robinet,Lucette Lacomblez,Philippe Couratier,Didier Hannequin,Danielle Seilhean,Isabelle Le Ber,Philippe Corcia,William Camu,Alexis Brice,Guy A. Rouleau,Eric LeGuern,Vincent Meininger +25 more
TL;DR: Clinical comparison of SOD1, TARDBP, FUS and other familial ALS patients (with no mutation in the screened genes) revealed differences in site of onset, age of onset (younger with FUS mutations), and in lifespan (shorter for FUS carriers).