P
Philippe d'Athis
Researcher at Paris Descartes University
Publications - 60
Citations - 2430
Philippe d'Athis is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Stiripentol & Placebo. The author has an hindex of 26, co-authored 60 publications receiving 2332 citations. Previous affiliations of Philippe d'Athis include University of Lausanne.
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Journal ArticleDOI
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial
Catherine Chiron,M.C. Marchand,A Tran,Elisabeth Rey,Philippe d'Athis,J. Vincent,Olivier Dulac,Gérard Pons +7 more
TL;DR: A controlled trial shows the antiepileptic efficacy, of add-on stiripentol in children with SMEI, and provides good reason to focus studies on a specific epilepsy syndrome.
Journal ArticleDOI
Stiripentol: efficacy and tolerability in children with epilepsy.
J. Perez,Catherine Chiron,C. Musial,E. Rey,H. Blehaut,Philippe d'Athis,J. Vincent,Olivier Dulac +7 more
TL;DR: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P450′ resulting in increased plasma concentrations of concomitant AEDs.
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A randomized, double‐blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children
L. Bertin,Gérard Pons,Philippe d'Athis,J.-F. Duhamel,C. Maudelonde,G. Lasfargues,M. Guillot,A Marsac,B Debregeas,Georges Olive +9 more
TL;DR: There is no argument to emphasize the utility of nonsteroidal anti‐inflammatory drugs (NSAIDs) in treating the inflammatory signs of the tympanic membrane in otitis and the efficacy of IBU was evidenced on the relief of pain, the symptom that most disturbs the child.
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Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
C. Cazeneuve,Gérard Pons,E. Rey,Jean-Marc Treluyer,T. Cresteil,G Thiroux,Philippe d'Athis,Georges Olive +7 more
TL;DR: The delay in the maturation of N-1 compared with N-3 and N-7-demethylation is in agreement with previous in vivo data, and the difference in maturational profiles of each metabolic pathway suggests that the reactions depend on different isoenzymes.
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Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant.
Françoise Hervé,Giulia Caron,Jean-Claude Duché,Patrick Gaillard,Noorsaadah Abd. Rahman,Anna Tsantili-Kakoulidou,Pierre-Alain Carrupt,Philippe d'Athis,Jean-Paul Tillement,Bernard Testa +9 more
TL;DR: This work determined the affinities of the two main gene products of AAG (i.e., the A variant and a mixture of the F1 and S variants) for 35 chemically diverse drugs and to obtain meaningful 3D-QSARs for each binding site.