C
Catherine E. Winbanks
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 23
Citations - 2660
Catherine E. Winbanks is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Skeletal muscle & Muscle hypertrophy. The author has an hindex of 16, co-authored 23 publications receiving 2289 citations. Previous affiliations of Catherine E. Winbanks include Royal Melbourne Hospital.
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Journal ArticleDOI
Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis.
Bo Wang,Radko Komers,Rosemarie M. Carew,Catherine E. Winbanks,Bei Xu,Michal Herman-Edelstein,Philip Koh,Merlin C. Thomas,Karin Jandeleit-Dahm,Paul Gregorevic,Mark E. Cooper,Phillip Kantharidis +11 more
TL;DR: It is suggested that TGF-β1 inhibits expression of the miR-29 family, thereby promoting expression of ECM components, and Pharmacologic modulation of these miRNAs may have therapeutic potential for progressive renal fibrosis.
Journal ArticleDOI
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
Bianca C. Bernardo,Xiao-Ming Gao,Catherine E. Winbanks,Esther J. H. Boey,Yow Keat Tham,Helen Kiriazis,Paul Gregorevic,Susanna Obad,Sakari Kauppinen,Xiao-Jun Du,Ruby C.Y. Lin,Julie R. McMullen +11 more
TL;DR: Evidence is provided that silencing of the entire miR-34 family can protect the heart against pathological cardiac remodeling and improve function and the utility of seed-targeting 8-mer LNA-antimiRs in the development of new therapeutic approaches for pharmacologic inhibition of disease-implicated miRNA seed families is underscored.
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miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
Bo Wang,Philip Koh,Catherine E. Winbanks,Melinda T. Coughlan,Aaron McClelland,Anna M.D. Watson,Karin Jandeleit-Dahm,Wendy C. Burns,Merlin C. Thomas,Mark E. Cooper,Phillip Kantharidis +10 more
TL;DR: These miRNAs appear to be intricately involved in fibrogenesis, both as downstream mediators of TGF-β signaling and as components of feedback regulation, and as such represent important new targets for the prevention of progressive kidney disease in the context of diabetes.
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TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4
Catherine E. Winbanks,Bo Wang,Claudia Beyer,Phillip Koh,Lloyd J. White,Phillip Kantharidis,Paul Gregorevic +6 more
TL;DR: A novel mechanism of interaction between TGF-β and miR-206 and -29 in the regulation of myogenic differentiation through HDAC4 is identified.
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miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7
Aaron McClelland,Aaron McClelland,Michal Herman-Edelstein,Radko Komers,Jay C. Jha,Catherine E. Winbanks,Shinji Hagiwara,Paul Gregorevic,Phillip Kantharidis,Mark E. Cooper +9 more
TL;DR: Data indicating that miR-21 up-regulation positively correlates with the severity of fibrosis and rate of decline in renal function in human DN is demonstrated, and concomitant analyses of various models of fibrotic renal disease and experimental DN, confirm tubular mi R-21Up-regulation.