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Xiao-Jun Du
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 184
Citations - 8477
Xiao-Jun Du is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Heart failure & Cardiac fibrosis. The author has an hindex of 49, co-authored 179 publications receiving 7328 citations. Previous affiliations of Xiao-Jun Du include The Heart Research Institute & Monash University, Clayton campus.
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Journal ArticleDOI
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
Bianca C. Bernardo,Xiao-Ming Gao,Catherine E. Winbanks,Esther J. H. Boey,Yow Keat Tham,Helen Kiriazis,Paul Gregorevic,Susanna Obad,Sakari Kauppinen,Xiao-Jun Du,Ruby C.Y. Lin,Julie R. McMullen +11 more
TL;DR: Evidence is provided that silencing of the entire miR-34 family can protect the heart against pathological cardiac remodeling and improve function and the utility of seed-targeting 8-mer LNA-antimiRs in the development of new therapeutic approaches for pharmacologic inhibition of disease-implicated miRNA seed families is underscored.
Journal ArticleDOI
Guidelines for experimental models of myocardial ischemia and infarction.
Merry L. Lindsey,Merry L. Lindsey,Roberto Bolli,John M. Canty,Xiao-Jun Du,Nikolaos G. Frangogiannis,Stefan Frantz,Robert G. Gourdie,Jeffrey W. Holmes,Steven P. Jones,Robert A. Kloner,Robert A. Kloner,David J. Lefer,Ronglih Liao,Elizabeth Murphy,Peipei Ping,Karin Przyklenk,Fabio A. Recchia,Fabio A. Recchia,Lisa Schwartz Longacre,Crystal M. Ripplinger,Jennifer E. Van Eyk,Gerd Heusch +22 more
TL;DR: The goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models and to provide increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results.
Journal ArticleDOI
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
Chrishan S. Samuel,Elaine N. Unemori,Ishanee Mookerjee,Ross A. D. Bathgate,Sharon Layfield,John Mak,Geoffrey W. Tregear,Xiao-Jun Du +7 more
TL;DR: It is indicated that relaxin regulates fibroblast proliferation, differentiation, and collagen deposition and may have therapeutic potential in diseased states characterized by cardiac fibrosis.
Journal ArticleDOI
Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
Michael J Kraakman,Helene L. Kammoun,Tamara L Allen,Virginie Deswaerte,Darren C. Henstridge,Emma Estevez,Vance B. Matthews,Bronwyn A Neill,David A. White,Andrew J. Murphy,Lone Peijs,Christine Yang,Steve Risis,Clinton R. Bruce,Xiao-Jun Du,Alex Bobik,Robert S. Lee-Young,Bronwyn A. Kingwell,Ajithkumar Vasanthakumar,Wei Shi,Wei Shi,Axel Kallies,Graeme I. Lancaster,Stefan Rose-John,Mark A. Febbraio +24 more
TL;DR: In this article, the authors show that IL-6 trans-signaling recruits macrophages into adipose tissue (ATM), but does not improve insulin action, and suggest that selectively blocking trans-Signaling with soluble gp130Fc protein may be a more favorable treatment option for inflammatory diseases.
Journal ArticleDOI
Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats
Edna D. Lekgabe,Helen Kiriazis,Chongxin Zhao,Qi Xu,Xiao-Lei Moore,Yidan Su,Ross A. D. Bathgate,Xiao-Jun Du,Chrishan S. Samuel +8 more
TL;DR: In this article, the antifibrotic effects of peptide hormone relaxin on cardiac and renal fibrosis were studied in 9- to 10-month-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY).