H
Helen Kiriazis
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 103
Citations - 4014
Helen Kiriazis is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Heart failure & Cardiac fibrosis. The author has an hindex of 31, co-authored 94 publications receiving 3306 citations.
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Journal ArticleDOI
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
Bianca C. Bernardo,Xiao-Ming Gao,Catherine E. Winbanks,Esther J. H. Boey,Yow Keat Tham,Helen Kiriazis,Paul Gregorevic,Susanna Obad,Sakari Kauppinen,Xiao-Jun Du,Ruby C.Y. Lin,Julie R. McMullen +11 more
TL;DR: Evidence is provided that silencing of the entire miR-34 family can protect the heart against pathological cardiac remodeling and improve function and the utility of seed-targeting 8-mer LNA-antimiRs in the development of new therapeutic approaches for pharmacologic inhibition of disease-implicated miRNA seed families is underscored.
Journal ArticleDOI
Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats
Edna D. Lekgabe,Helen Kiriazis,Chongxin Zhao,Qi Xu,Xiao-Lei Moore,Yidan Su,Ross A. D. Bathgate,Xiao-Jun Du,Chrishan S. Samuel +8 more
TL;DR: In this article, the antifibrotic effects of peptide hormone relaxin on cardiac and renal fibrosis were studied in 9- to 10-month-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY).
Journal ArticleDOI
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
Jorg-Detlef Christian Drenckhahn,Quenten Schwarz,Stephen P. Gray,Adrienne Laskowski,Helen Kiriazis,Ziqiu Ming,Richard P. Harvey,Xiao-Jun Du,David R. Thorburn,David R. Thorburn,Timothy C. Cox,Timothy C. Cox,Timothy C. Cox +12 more
TL;DR: An impressive regenerative capacity of the fetal heart that can compensate for an effective loss of 50% of cardiac tissue is revealed by increased proliferation of remaining healthy cardiac cells resulting in a fully functional heart.
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PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Ruby C.Y. Lin,Kate L. Weeks,Xiao-Ming Gao,Rohan B.H. Williams,Bianca C. Bernardo,Helen Kiriazis,Vance B. Matthews,Elizabeth A. Woodcock,Russell Bouwman,Janelle Mollica,Helen Speirs,Ian W. Dawes,Roger J. Daly,Tetsuo Shioi,Seigo Izumo,Mark A. Febbraio,Xiao-Jun Du,Julie R. McMullen +17 more
TL;DR: Assessment of whether PI3K(p110&agr;) is beneficial in a setting of MI and to identify cardiac-selective microRNA and mRNA that mediate the protective properties of PI3k(p 110&agR;) indicates new drug targets for heart failure.
Journal ArticleDOI
Reduced Phosphoinositide 3-Kinase (p110α) Activation Increases the Susceptibility to Atrial Fibrillation
Lynette Pretorius,Lynette Pretorius,Xiao-Jun Du,Elizabeth A. Woodcock,Helen Kiriazis,Ruby C.Y. Lin,Silvana Marasco,Robert L. Medcalf,Ziqiu Ming,Geoffrey A. Head,Joon Win Tan,Nelly Cemerlang,Junichi Sadoshima,Tetsuo Shioi,Seigo Izumo,Elena V Lukoshkova,Anthony M. Dart,Anthony M. Dart,Garry L. Jennings,Julie R. McMullen +19 more
TL;DR: In atrial appendages from patients with AF, PI3K activation was lower compared with tissue from patients in sinus rhythm, suggesting a link between PI3k(p110alpha) and AF.