Showing papers by "Cécile M. Ronckers published in 2013"
Boston Children's Hospital1, St. Jude Children's Research Hospital2, City of Hope National Medical Center3, Great Ormond Street Hospital4, University of Rochester Medical Center5, Royal Hospital for Sick Children6, Netherlands Cancer Institute7, University of Chicago8, Royal Victoria Infirmary9, Memorial Sloan Kettering Cancer Center10
TL;DR: In this article, the authors applied evidence-based methods to develop international, harmonised recommendations for breast cancer surveillance among female survivors of childhood, adolescent, and young adult (CAYA) cancer who were given radiation to fields that include breast tissue (ie, chest radiation) have an increased risk of breast cancer.
Abstract: Summary Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were given radiation to fields that include breast tissue (ie, chest radiation) have an increased risk of breast cancer. Clinical practice guidelines are essential to ensure that these individuals receive optimum care and to reduce the detrimental consequences of cancer treatment; however, surveillance recommendations vary among the existing long-term follow-up guidelines. We applied evidence-based methods to develop international, harmonised recommendations for breast cancer surveillance among female survivors of CAYA cancer who were given chest radiation before age 30 years. The recommendations were formulated by an international, multidisciplinary panel and are graded according to the strength of the underlying evidence.
161 citations
National Institutes of Health1, French Institute of Health and Medical Research2, Memorial Sloan Kettering Cancer Center3, Stanford University4, Lund University5, Fred Hutchinson Cancer Research Center6, Nationwide Children's Hospital7, Emory University8, University of Texas MD Anderson Cancer Center9
TL;DR: Three absolute risk models for second primary thyroid cancer were developed and validated to assist with long-term clinical monitoring of childhood cancer survivors and found model M2, with basic prior treatment information, could be useful for monitoring thyroid cancer risk in Childhood cancer survivors.
Abstract: Purpose We developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors. Patients and Methods We used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chemotherapy treatment information abstracted from medical records, and model M3 refined M2 by incorporating reconstructed radiation absorbed dose to the thyroid. All models were validated in an independent cohort of French childhood cancer survivors. Results M1 included birth year, initial cancer type, age at diagnosis, sex, and past thyroid nodule diagnosis. M2 added radiation (yes/no), radiation to the neck (yes/no), and alkylating agent (yes/no). Past thyroid nodule was consistently the strongest risk factor (M1 relative risk [RR], 10.8; M2 RR, 6.8; M3 RR, 8.2). In the validation cohort, 20-year absolute risk p...
44 citations
TL;DR: It is confirmed that CRT increases the prevalence and severity of AEs in childhood cancer survivors and analyzing dose-effect relationships with the cumulative EQD(2) instead of total physical dose connects the knowledge from radiation therapy and radiobiology with the clinical experience.
Abstract: Purpose To evaluate the prevalence and severity of clinical adverse events (AEs) and treatment-related risk factors in childhood cancer survivors treated with cranial radiation therapy (CRT), with the aim of assessing dose-effect relationships Methods and Materials The retrospective study cohort consisted of 1362 Dutch childhood cancer survivors, of whom 285 were treated with CRT delivered as brain irradiation (BI), as part of craniospinal irradiation (CSI), and as total body irradiation (TBI) Individual CRT doses were converted into the equivalent dose in 2-Gy fractions (EQD 2 ) Survivors had received their diagnoses between 1966 and 1996 and survived at least 5 years after diagnosis A complete inventory of Common Terminology Criteria for Adverse Events grade 30 AEs was available from our hospital-based late-effect follow-up program We used multivariable logistic and Cox regression analyses to examine the EQD 2 in relation to the prevalence and severity of AEs, correcting for sex, age at diagnosis, follow-up time, and the treatment-related risk factors surgery and chemotherapy Results There was a high prevalence of AEs in the CRT group; over 80% of survivors had more than 1 AE, and almost half had at least 5 AEs, both representing significant increases in number of AEs compared with survivors not treated with CRT Additionally, the proportion of severe, life-threatening, or disabling AEs was significantly higher in the CRT group The most frequent AEs were alopecia and cognitive, endocrine, metabolic, and neurologic events Using the EQD 2 , we found significant dose-effect relationships for these and other AEs Conclusion Our results confirm that CRT increases the prevalence and severity of AEs in childhood cancer survivors Furthermore, analyzing dose-effect relationships with the cumulative EQD 2 instead of total physical dose connects the knowledge from radiation therapy and radiobiology with the clinical experience
33 citations