C
Cedric E. Snethlage
Researcher at University of California, San Francisco
Publications - 7
Citations - 436
Cedric E. Snethlage is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 3 publications receiving 270 citations.
Papers
More filters
Journal ArticleDOI
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Lucas K. Smith,Yingbo He,Jeong Soo Park,Gregor Bieri,Cedric E. Snethlage,Karin Lin,Geraldine Gontier,Rafael Wabl,Kristopher E Plambeck,Joe C. Udeochu,Elizabeth G. Wheatley,Jill Bouchard,Alexander Eggel,Ramya Narasimha,Jacqueline L Grant,Jian Luo,Tony Wyss-Coray,Saul A. Villeda +17 more
TL;DR: In this paper, the authors identify β2-microglobulin (B2M), a component of major histocompatibility complex class 1 (MHC I) molecules, as a circulating factor that negatively regulates cognitive and regenerative function in the adult hippocampus.
Journal ArticleDOI
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain
Elizabeth G. Wheatley,Eddy Albarran,Charles W. White,Gregor Bieri,Cesar Sanchez-Diaz,Karishma Pratt,Cedric E. Snethlage,Jun B. Ding,Saul A. Villeda +8 more
TL;DR: It is reported that countering age-related decreased O- GlcNAc transferase (OGT) expression and O-GlcNAcylation ameliorates cognitive impairments in aged mice and identifies O-glcNAcylaton as a key molecular mediator promoting cognitive rejuvenation.
Journal ArticleDOI
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
Pinar Mesci,Janaina Sena de Souza,Laura Martin-Sancho,Angela Macia,Aurian Saleh,Xin Yin,Cedric E. Snethlage,Jason W. Adams,Simoni Helena Avansini,Roberto H. Herai,Angels Almenar-Queralt,Yuan Pu,Ryan A. Szeto,Gabriela Goldberg,Patrick T Bruck,Fabio Papes,Sumit K. Chanda,Alysson R. Muotri +17 more
TL;DR: In this article , the authors show that SARS-CoV-2 can productively replicate and promote death of neural cells, including cortical neurons, accompanied by loss of excitatory synapses in neurons.
Journal ArticleDOI
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling.
Karin Lin,Gregor Bieri,Geraldine Gontier,Sören Müller,Lucas K. Smith,Cedric E. Snethlage,Charles W. White,Sun Y. Maybury-Lewis,Saul A. Villeda +8 more
TL;DR: In this article, the authors identify classical MHC I molecule H2-Kb as a negative regulator of proliferation in neural stem and progenitor cells (NSPCs).
Posted ContentDOI
CADM2 is implicated in impulsive personality traits by genome- and phenome-wide association studies in humans, with further support from studies of Cadm2 mutant mice
Sandra Sanchez-Roige,Mariela V Jennings,Hayley H. A. Thorpe,Jazlene E. Mallari,Lieke van der Werf,Sevim B Bianchi,Calvin Lee,Travis T. Mallard,Samuel A. Barnes,Jin Wu,Amanda M. Barkley-Levenson,Ely C. Boussaty,Cedric E. Snethlage,Zeljana Babic,Boyer D. Winters,Katherine Watters,Thomas Biederer,James MacKillop,David N. Stephens,Sarah L. Elson,Pierre Fontanillas,Jibran Y. Khokhar,Jared W. Young,Abraham A. Palmer +23 more
TL;DR: The role of CADM2 in impulsivity and numerous other psychiatric and somatic traits across ancestries are established and it is demonstrated that deletion of Cadm2 in mice influences behavior in assays designed to measure impulsive and risky behavior.