S
Sumit K. Chanda
Researcher at Discovery Institute
Publications - 122
Citations - 18346
Sumit K. Chanda is an academic researcher from Discovery Institute. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 42, co-authored 110 publications receiving 12333 citations. Previous affiliations of Sumit K. Chanda include Sanford-Burnham Institute for Medical Research & Stanford University.
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Journal ArticleDOI
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Yingyao Zhou,Bin Zhou,Lars Pache,Max W. Chang,Alireza Hadj Khodabakhshi,Olga Tanaseichuk,Christopher Benner,Sumit K. Chanda +7 more
TL;DR: A biologist-oriented portal that provides a gene list annotation, enrichment and interactome resource and enables integrated analysis of multi-OMICs datasets, Metascape is an effective and efficient tool for experimental biologists to comprehensively analyze and interpret OMICs-based studies in the big data era.
Journal ArticleDOI
Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication
Renate König,Yingyao Zhou,Daniel Elleder,Tracy L. Diamond,Ghislain M. C. Bonamy,Jeffrey T. Irelan,Chih-yuan Chiang,Buu P. Tu,Paul D. De Jesus,Caroline E. Lilley,Shannon Seidel,Amanda M. Opaluch,Jeremy S. Caldwell,Matthew D. Weitzman,Kelli Kuhen,Sourav Bandyopadhyay,Trey Ideker,Anthony P. Orth,Loren Miraglia,Frederic D. Bushman,John A. T. Young,Sumit K. Chanda +21 more
TL;DR: A multiscale approach to assemble a host-pathogen biochemical network containing 213 confirmed host cellular factors and 11 HIV-1-encoded proteins has uncovered multiprotein virus-host interactions that likely act in concert to facilitate the early steps of HIV- 1 infection.
Journal ArticleDOI
Human host factors required for influenza virus replication
Renate König,Silke Stertz,Yingyao Zhou,Atsushi Inoue,H.-Heinrich Hoffmann,Suchita Bhattacharyya,Judith G. Alamares,Donna M. Tscherne,Mila Brum Ortigoza,Yuhong Liang,Qinshan Gao,Shane E. Andrews,Sourav Bandyopadhyay,Paul D. De Jesus,Buu P. Tu,Lars Pache,Crystal Shih,Anthony P. Orth,Ghislain M. C. Bonamy,Loren Miraglia,Trey Ideker,Adolfo García-Sastre,John A. T. Young,Peter Palese,Megan L. Shaw,Sumit K. Chanda +25 more
TL;DR: This work uses an integrative systems approach, based on genome-wide RNA interference screening, to identify 295 cellular cofactors required for early-stage influenza virus replication, and identifies those involved in kinase-regulated signalling, ubiquitination and phosphatase activity as the most highly enriched.
Journal ArticleDOI
Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
Shashank Tripathi,Marie O. Pohl,Yingyao Zhou,Ariel Rodriguez-Frandsen,Guojun Wang,David A. Stein,Hong M. Moulton,Paul DeJesus,Jianwei Che,Lubbertus C. F. Mulder,Emilio Yángüez,Dario Andenmatten,Lars Pache,Balaji Manicassamy,Randy A. Albrecht,Maria G. Gonzalez,Quy T. Nguyen,Abraham L. Brass,Stephen J. Elledge,Stephen J. Elledge,Michael A. White,Sagi Shapira,Nir Hacohen,Alexander Karlas,Thomas F. Meyer,Michael Shales,Andre Gatorano,Jeffrey R. Johnson,Gwen Jang,Tasha L. Johnson,Erik Verschueren,Doug Sanders,Nevan J. Krogan,Megan L. Shaw,Renate König,Renate König,Silke Stertz,Adolfo García-Sastre,Sumit K. Chanda +38 more
TL;DR: A meta-analysis of data from eight published RNAi screens and integrated with three protein interaction datasets revealed a functionally validated biochemical landscape of the influenza-host interface, which illuminates a viral-host network of high-confidence human proteins that are essential for influenza A virus replication.
Journal ArticleDOI
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling
Wei Li,Mario H. Bengtson,Axel Ulbrich,Akio Matsuda,Venkateshwar A. Reddy,Anthony P. Orth,Sumit K. Chanda,Serge Batalov,Claudio A. P. Joazeiro +8 more
TL;DR: It is found that MULAN is a mitochondrial protein – two transmembrane domains mediate its localization to the organelle's outer membrane, suggesting the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment.