A
Alysson R. Muotri
Researcher at University of California, San Diego
Publications - 247
Citations - 17552
Alysson R. Muotri is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Induced pluripotent stem cell & Neural stem cell. The author has an hindex of 53, co-authored 209 publications receiving 14677 citations. Previous affiliations of Alysson R. Muotri include Torrey Pines Institute for Molecular Studies & University of São Paulo.
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Journal ArticleDOI
A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
Maria C. Marchetto,Cassiano Carromeu,Allan Acab,Diana Yu,Gene W. Yeo,Yangling Mu,Gong Chen,Fred H. Gage,Alysson R. Muotri +8 more
TL;DR: The model recapitulates early stages of a human neurodevelopmental disease and represents a promising cellular tool for drug screening, diagnosis and personalized treatment and provides evidence of an unexplored developmental window, before disease onset, in RTT syndrome.
Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
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Human embryonic stem cells express an immunogenic nonhuman sialic acid
TL;DR: Levels of Neu5Gc on HESC and embryoid bodies dropped after culture in heat-inactivated anti-Neu5 Gc antibody–negative human serum, reducing binding of antibodies and complement from high-titer sera, while allowing maintenance of the undifferentiated state.
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Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
TL;DR: It is shown that an engineered human LINE-1 element can retrotranspose in neuronal precursors derived from rat hippocampus neural stem cells, indicating that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events.
Journal ArticleDOI
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
Tomoko Kuwabara,Jenny Hsieh,Alysson R. Muotri,Gene W. Yeo,Masaki Warashina,Masaki Warashina,Dieter Chichung Lie,Lynne Moore,Kinichi Nakashima,Makoto Asashima,Fred H. Gage +10 more
TL;DR: A previously unknown Wnt-mediated regulatory mechanism that simultaneously coordinates activation of NeuroD1 and LINE-1 is described, which is important for adult neurogenesis and survival of neuronal progenitors.