C
Cedric S. Raine
Researcher at Albert Einstein College of Medicine
Publications - 296
Citations - 27558
Cedric S. Raine is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Myelin & Multiple sclerosis. The author has an hindex of 82, co-authored 296 publications receiving 26593 citations. Previous affiliations of Cedric S. Raine include Yeshiva University & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
Christopher Lock,Guy Hermans,Rosetta Pedotti,Andrea Brendolan,Eric E. Schadt,Hideki Garren,Annette Langer-Gould,Samuel Strober,Barbara Cannella,John Allard,Klonowski Paul,Angela Austin,Nagin Lad,Naftali Kaminski,Stephen J. Galli,Jorge R. Oksenberg,Cedric S. Raine,Renu A. Heller,Lawrence Steinman +18 more
TL;DR: Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy, and results in EAE corroborate the microarray studies on MS lesions.
Journal ArticleDOI
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Krzysztof Selmaj,Cedric S. Raine +1 more
TL;DR: It appears that a physiological (not structural) demyelination occurs initially without overt destruction of the myelin sheath, relevant to the evolution of the multiple sclerosis plaque: dysfunction of ionic channels might contribute to the eventual demise of oligodendrocytes and axons in the longstanding lesion.
Journal ArticleDOI
Identification of autoantibodies associated with myelin damage in multiple sclerosis
TL;DR: These findings represent direct evidence that autoantibodies against a specific myelin protein mediate target membrane damage in central nervous system demyelinating disease.
Journal ArticleDOI
Glutamate excitotoxicity in a model of multiple sclerosis
TL;DR: Glutamate excitotoxicity seems to be an important mechanism in autoimmune demyelination, and its prevention with AMPA/kainate antagonists may prove to be a effective therapy for multiple sclerosis.
Journal ArticleDOI
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.
Michael K. Racke,A Bonomo,Dorothy E. Scott,Barbara Cannella,Alan M. Levine,Cedric S. Raine,Ethan M. Shevach,Martin Röcken +7 more
TL;DR: Modulation of an immune response from one dominated by excessive activity of Th1-like T cells to onedominated by the protective cytokines produced by Th2- like T cells may have applicability to the therapy of certain human autoimmune diseases.