Chai Yin Kok

TL;DR: Improvements to the public website and data-download systems and new functionality in COSMIC-3D allows exploration of mutations within three-dimensional protein structures, their protein structural and functional impacts, and implications for druggability.

TL;DR: With all genomic information recently updated to GRCh37, COSMIC integrates many diverse types of mutation information and is making much closer links with Ensembl and other data resources.

TL;DR: COSMIC, the Catalogue Of Somatic Mutations In Cancer is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer, describing 2 002 811 coding point mutations in over one million tumor samples and across most human genes.

TL;DR: COSMIC v78 contains wide resistance mutation profiles across 20 drugs, detailing the recurrence of 301 unique resistance alleles across 1934 drug-resistant tumours.

TL;DR: The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.