T
Tatiana Mironenko
Researcher at Wellcome Trust Sanger Institute
Publications - 17
Citations - 10576
Tatiana Mironenko is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 15, co-authored 15 publications receiving 9278 citations.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
Systematic identification of genomic markers of drug sensitivity in cancer cells
Mathew J. Garnett,Elena J. Edelman,Sonja J. Heidorn,Christopher Greenman,Christopher Greenman,Anahita Dastur,King Wai Lau,Patricia Greninger,I. Richard Thompson,Xi Luo,Jorge Soares,Qingsong Liu,Francesco Iorio,Francesco Iorio,Didier Surdez,Li Chen,Randy J. Milano,Graham R. Bignell,Ah Ting Tam,Helen Davies,Jesse A. Stevenson,Syd Barthorpe,Stephen R. Lutz,Fiona Kogera,Karl P. Lawrence,Anne McLaren-Douglas,Xeni Mitropoulos,Tatiana Mironenko,Helen Thi,Laura Richardson,Wenjun Zhou,F Jewitt,Tinghu Zhang,Patrick O’Brien,Jessica L. Boisvert,Stacey Price,Wooyoung Hur,Wanjuan Yang,Xianming Deng,Adam Butler,Hwan Geun Choi,Jae Won Chang,José Baselga,Ivan Stamenkovic,Jeffrey A. Engelman,Sreenath V. Sharma,Sreenath V. Sharma,Olivier Delattre,Julio Saez-Rodriguez,Nathanael S. Gray,Jeffrey Settleman,P. Andrew Futreal,Daniel A. Haber,Daniel A. Haber,Michael R. Stratton,Sridhar Ramaswamy,Ultan McDermott,Cyril H. Benes +57 more
TL;DR: It was found that mutated cancer genes were associated with cellular response to most currently available cancer drugs, and systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.
Journal ArticleDOI
A Landscape of Pharmacogenomic Interactions in Cancer
Francesco Iorio,Francesco Iorio,Theo A. Knijnenburg,Theo A. Knijnenburg,Daniel J. Vis,Graham R. Bignell,Michael P. Menden,Michael P. Menden,Michael Schubert,Nanne Aben,Nanne Aben,Emanuel Gonçalves,Syd Barthorpe,Howard Lightfoot,Thomas Cokelaer,Thomas Cokelaer,Patricia Greninger,Ewald van Dyk,Han Chang,Heshani de Silva,Holger Heyn,Xianming Deng,Regina K. Egan,Qingsong Liu,Tatiana Mironenko,Xeni Mitropoulos,Laura Richardson,Jinhua Wang,Tinghu Zhang,Sebastian Moran,Sergi Sayols,Maryam Soleimani,David Tamborero,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Petra Ross-Macdonald,Manel Esteller,Manel Esteller,Nathanael S. Gray,Daniel A. Haber,Daniel A. Haber,Michael R. Stratton,Cyril H. Benes,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Ultan McDermott,Mathew J. Garnett +48 more
TL;DR: It is reported how cancer-driven alterations identified in 11,289 tumors from 29 tissues can be mapped onto 1,001 molecularly annotated human cancer cell lines and correlated with sensitivity to 265 drugs.
Journal ArticleDOI
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Gillian L. Dalgliesh,Kyle A. Furge,Christopher Greenman,Lina Chen,Graham R. Bignell,Adam Butler,Helen Davies,Sarah Edkins,Claire Hardy,Calli Latimer,Jon W. Teague,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Simon A. Forbes,Mingming Jia,David T. Jones,Henry Knott,Chai Yin Kok,King Wai Lau,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maguire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Sarah O’Meara,Erin Pleasance,Aarjunan Rajasingham,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Kelly Turrell,Karl Dykema,Sok Kean Khoo,David Petillo,Bill Wondergem,John Anema,Richard J. Kahnoski,Bin Tean Teh,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +52 more
TL;DR: The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.
Journal ArticleDOI
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Gijs van Haaften,Gillian L. Dalgliesh,Helen Davies,Lina Chen,Graham R. Bignell,Christopher Greenman,Sarah Edkins,Claire Hardy,Sarah O’Meara,Jon W. Teague,Adam Butler,Jonathan Hinton,Calli Latimer,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Jennifer Cole,Simon A. Forbes,Mingming Jia,David T. Jones,Chai Yin Kok,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maquire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Erin Pleasance,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Rachel Turner,Kelly Turrell,Jennifer Varian,Sofie West,Sara Widaa,Paul Wray,V. Peter Collins,Koichi Ichimura,Simon Law,John Wong,Siu Tsan Yuen,Suet Yi Leung,Giovanni Tonon,Giovanni Tonon,Ronald A. DePinho,Yu-Tzu Tai,Kenneth C. Anderson,Richard J. Kahnoski,Aaron Massie,Sok Kean Khoo,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +63 more
TL;DR: UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes, identifying UTX as a new human cancer gene.