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Henry Knott
Researcher at Wellcome Trust Sanger Institute
Publications - 1
Citations - 1115
Henry Knott is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer epigenetics & Cancer. The author has an hindex of 1, co-authored 1 publications receiving 1053 citations.
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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Gillian L. Dalgliesh,Kyle A. Furge,Christopher Greenman,Lina Chen,Graham R. Bignell,Adam Butler,Helen Davies,Sarah Edkins,Claire Hardy,Calli Latimer,Jon W. Teague,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Simon A. Forbes,Mingming Jia,David T. Jones,Henry Knott,Chai Yin Kok,King Wai Lau,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maguire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Sarah O’Meara,Erin Pleasance,Aarjunan Rajasingham,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Kelly Turrell,Karl Dykema,Sok Kean Khoo,David Petillo,Bill Wondergem,John Anema,Richard J. Kahnoski,Bin Tean Teh,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +52 more
TL;DR: The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.