John Anema

TL;DR: The protein coding exome is sequenced in a series of primary ccRCC and the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 is reported as a second majorccRCC cancer gene, with truncating mutations in 41% (92/227) of cases.

TL;DR: The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.

TL;DR: Two molecular subclasses of PRCC are reported, which are biologically and clinically distinct and may be readily distinguished in a clinical setting and identified two highly distinct molecular PRCC subclasses with morphologic correlation.

TL;DR: It is suggested that overexpression of S-has-miR-32 is associated with poor outcome and the utility of miRNA expression profiling to identify a signature unique to various tumor subtypes at a single anatomic locus is demonstrated.

TL;DR: In this article, the authors show that mutations in NRF2, CUL3, and SIRT1 are responsible for driving the activation phenotype in sporadic PRCC2 transcriptome sequencing.