S
Sok Kean Khoo
Researcher at Grand Valley State University
Publications - 73
Citations - 8771
Sok Kean Khoo is an academic researcher from Grand Valley State University. The author has contributed to research in topics: Germline mutation & Cancer. The author has an hindex of 32, co-authored 71 publications receiving 8179 citations. Previous affiliations of Sok Kean Khoo include Tokyo University of Marine Science and Technology & Van Andel Institute.
Papers
More filters
Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Gillian L. Dalgliesh,Kyle A. Furge,Christopher Greenman,Lina Chen,Graham R. Bignell,Adam Butler,Helen Davies,Sarah Edkins,Claire Hardy,Calli Latimer,Jon W. Teague,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Simon A. Forbes,Mingming Jia,David T. Jones,Henry Knott,Chai Yin Kok,King Wai Lau,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maguire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Sarah O’Meara,Erin Pleasance,Aarjunan Rajasingham,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Kelly Turrell,Karl Dykema,Sok Kean Khoo,David Petillo,Bill Wondergem,John Anema,Richard J. Kahnoski,Bin Tean Teh,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +52 more
TL;DR: The identification of inactivating mutations in two genes encoding enzymes involved in histone modification and NF2 mutations were found in non-VHL mutated ccRCC, and several other probable cancer genes were identified, indicating that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene.
Journal ArticleDOI
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Gijs van Haaften,Gillian L. Dalgliesh,Helen Davies,Lina Chen,Graham R. Bignell,Christopher Greenman,Sarah Edkins,Claire Hardy,Sarah O’Meara,Jon W. Teague,Adam Butler,Jonathan Hinton,Calli Latimer,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Jennifer Cole,Simon A. Forbes,Mingming Jia,David T. Jones,Chai Yin Kok,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maquire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Erin Pleasance,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Rachel Turner,Kelly Turrell,Jennifer Varian,Sofie West,Sara Widaa,Paul Wray,V. Peter Collins,Koichi Ichimura,Simon Law,John Wong,Siu Tsan Yuen,Suet Yi Leung,Giovanni Tonon,Giovanni Tonon,Ronald A. DePinho,Yu-Tzu Tai,Kenneth C. Anderson,Richard J. Kahnoski,Aaron Massie,Sok Kean Khoo,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +63 more
TL;DR: UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes, identifying UTX as a new human cancer gene.
Journal ArticleDOI
A Microsatellite Linkage Map of Rainbow Trout (Oncorhynchus mykiss) Characterized by Large Sex-Specific Differences in Recombination Rates
Takashi Sakamoto,Roy G. Danzmann,Karim Gharbi,Pamela Howard,Akiyuki Ozaki,Sok Kean Khoo,Rachael A. Woram,Nobuaki Okamoto,Moira M. Ferguson,Lars-Erik Holm,René Guyomard,Bjørn Høyheim +11 more
TL;DR: A genetic linkage map for a tetraploid derivative species, the rainbow trout (Oncorhynchus mykiss), using 191 microsatellite, 3 RAPD, 7 ESMP, and 7 allozyme markers in three backcross families is constructed.
Journal ArticleDOI
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours
Viive M. Howell,Carola J. Haven,K. Kahnoski,Sok Kean Khoo,David Petillo,Jindong Chen,Gert Jan Fleuren,Bruce G. Robinson,Leigh Delbridge,Jeanette Philips,Anne E. Nelson,Ulf Krause,K. Hammje,Henning Dralle,Cuong Hoang-Vu,Oliver Gimm,Deborah J. Marsh,Hans Morreau,Bin Tean Teh +18 more
TL;DR: The results in this study support the role of HRPT2 as a tumour suppressor gene in sporadic parathyroid carcinoma, and provide further evidence for HRPT 2 as the causative gene in HPT-JT, and a subset of FIHP.