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Chanan Rubin

Researcher at Weizmann Institute of Science

Publications -  9
Citations -  1332

Chanan Rubin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Receptor tyrosine kinase & Ubiquitin ligase. The author has an hindex of 9, co-authored 9 publications receiving 1285 citations.

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LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

TL;DR: It is concluded that LRIG1 evolved in mammals as a feedback negative attenuator of signaling by receptor tyrosine kinases by upregulation ofLRIG1 transcript and protein upon EGF stimulation, and physical association of the encoded protein with the four EGFR orthologs of mammals.
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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

TL;DR: It is reported that defective Tyr1045 of EGFR, an inducible c‐Cbl docking site, enhances the mitogenic response to EGF, and Grb2 can terminate signal transduction by accelerating c-Cbl‐dependent sorting of active tyrosine kinases to destruction.
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Drug‐induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

TL;DR: An unexpected activity of TKIs is reported: along with inhibition of tyrosine phosphorylation, they enhance ubiquitylation and accelerate endocytosis and subsequent intracellular destruction of ErbB‐2 molecules.
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Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.

TL;DR: Sprouty2 emerges as an inducible antagonist of c-Cbl, and together they set a time window for receptor activation, which regulates the amplitude and longevity of intracellular signals.
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Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation.

TL;DR: While Cbl-mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated.