C
Chandrima Shaha
Researcher at Population Council
Publications - 78
Citations - 3811
Chandrima Shaha is an academic researcher from Population Council. The author has contributed to research in topics: Apoptosis & Leishmania donovani. The author has an hindex of 34, co-authored 77 publications receiving 3520 citations. Previous affiliations of Chandrima Shaha include Semmelweis University.
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Male germ cell apoptosis: regulation and biology
TL;DR: This review discusses the latest information available on male germ cell apoptosis induced by hormones, toxins and temperature in the context of the type of apoptotic pathway either the intrinsic or the extrinsic that may be used under a variety of stimuli.
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Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes
TL;DR: Exposure to 4 mM H2O2 results in a pattern of promastigote death that shares many features with metazoan apoptosis, showing for the first time that there is a distinct pathway for apoptosis-like death in L. donovani.
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Increase in Cytosolic Ca2+ Levels through the Activation of Non-selective Cation Channels Induced by Oxidative Stress Causes Mitochondrial Depolarization Leading to Apoptosis-like Death in Leishmania donovaniPromastigotes *
TL;DR: Findings show the importance of non-selective cation channels in regulating the response of L. donovanipromastigotes to oxidative stress that triggers downstream signaling cascades leading to apoptosis-like death.
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Apoptotic Death in Leishmania donovani Promastigotes in Response to Respiratory Chain Inhibition COMPLEX II INHIBITION RESULTS IN INCREASED PENTAMIDINE CYTOTOXICITY
Ashish Mehta,Chandrima Shaha +1 more
TL;DR: This study provides a new possibility that concurrent inhibition of respiratory chain complex II with pentamidine administration increases cytotoxicity of the drug, and leads to inhibition of complexes I, II, and III leads to apoptosis and complex II inhibition in parallel with pentAMidine administration-enhanced drug efficacy.
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Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes.
TL;DR: The importance of flufenamic acid-sensitive non-selective cation channels as important modulators of antimonial efficacy is projected and lends credence to the suggestion that, within the host cell, apoptosis is the preferred mode of death for the parasites.