C
Chansavath Phetsouphanh
Researcher at University of Oxford
Publications - 30
Citations - 508
Chansavath Phetsouphanh is an academic researcher from University of Oxford. The author has contributed to research in topics: T cell & Population. The author has an hindex of 12, co-authored 25 publications receiving 384 citations. Previous affiliations of Chansavath Phetsouphanh include University of New South Wales & St. Vincent's Health System.
Papers
More filters
Journal ArticleDOI
Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes
Elissa L Sutcliffe,Karen L. Bunting,Yi Qing He,Jasmine Li,Chansavath Phetsouphanh,Nabila Seddiki,Anjum Zafar,Elizabeth J. Hindmarsh,Christopher R. Parish,Anthony D. Kelleher,Russell L. McInnes,Toshiki Taya,Peter J. Milburn,Sudha Rao,Sudha Rao +14 more
TL;DR: Evidence is provided for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in human T cells, and ChIP-on-chip reveals that PKC- θ binds to promoters and transcribed regions of genes, as well as to microRNA promoters that are crucial for cytokine regulation.
Journal ArticleDOI
Human antigen‐specific CD4+CD25+CD134+CD39+ T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses
Nabila Seddiki,Laura Cook,Denise C. Hsu,Chansavath Phetsouphanh,Kai Brown,Yin Xu,Stephen J. Kerr,David A. Cooper,David A. Cooper,C Mee Ling Munier,Sarah Pett,Jintanat Ananworanich,John Zaunders,Anthony D. Kelleher,Anthony D. Kelleher +14 more
TL;DR: The data show that Ag‐specific CD4+CD25+CD134+CD39+ T cells are highly enriched for Treg cells, form a large component of recall responses and maintain a Treg‐cell‐like phenotype upon in vitro expansion.
Journal ArticleDOI
The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection
Nabila Seddiki,Chansavath Phetsouphanh,Sanjay Swaminathan,Yin Xu,Sudha Rao,Jasmine Li,Elissa L Sutcliffe,Gareth Denyer,Robert Finlayson,Linda Gelgor,David A. Cooper,John Zaunders,Anthony D. Kelleher +12 more
TL;DR: It is demonstrated that B‐lymphocyte‐induced maturation protein‐1 (Blimp‐1/Prdm1) is highly expressed in CD4+ T cells from chronically HIV‐infected (CHI) patients compared to cells from long‐term nonprogressors or healthy controls.
Journal ArticleDOI
CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.
Genevieve E. Martin,M Pace,John Thornhill,John Thornhill,Chansavath Phetsouphanh,J Meyerowitz,Morgane Gossez,Helen Brown,Natalia Olejniczak,Julianne Lwanga,Gita Ramjee,Pontiano Kaleebu,Kholoud Porter,Christian B. Willberg,Paul Klenerman,Nneka Nwokolo,Julie Fox,Sarah Fidler,John Frater +18 more
TL;DR: The data suggest that while CD32+ T cells can be infected with HIV, CD32 is not a specific marker of the reservoir although it might identify a population of HIV enriched cells in certain situations.
Journal ArticleDOI
Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells.
TL;DR: Detailed analysis of clonally related antigen-specific T cells using single-cell TCR RNA-seq will provide information on pathways of differentiation of memory T cells and with these state of the art technologies the transcriptomics and genomics of Ag- specific T cells can be more definitively elucidated.