J
John Thornhill
Researcher at Imperial College London
Publications - 42
Citations - 1515
John Thornhill is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 10, co-authored 32 publications receiving 455 citations. Previous affiliations of John Thornhill include University of Oxford & Barts Health NHS Trust.
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Journal ArticleDOI
Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022.
John Thornhill,Sapha Barkati,Sharon Walmsley,Juergen K. Rockstroh,Andrea Antinori,Luke B Harrison,Romain Palich,Achyuta V Nori,I. Reeves,Maximillian S. Habibi,Vanessa Apea,Christoph Boesecke,Linos Vandekerckhove,M. V. Yakubovsky,Elena Sendagorta,José L. Blanco,Eric Florence,Davide Moschese,Fernando Maltez,Abraham Goorhuis,Valérie Pourcher,Pascal Migaud,Sebastian Noe,Claire Pintado,Fabrizio Maggi,Ann-Brit Eg Hansen,Christian Hoffmann,Jezer I Lezama,Cristina Mussini,Anna Maria Cattelan,Keletso Makofane,Darrell H. S. Tan,Silvia Nozza,J. Nemeth,Marina B Klein,Chloe Orkin +35 more
TL;DR: The simultaneous identification of cases outside areas where monkeypox has traditionally been endemic highlights the need for rapid identification and diagnosis of cases to contain further community spread.
Journal ArticleDOI
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
Jacob Hurst,Matthias Hoffmann,M Pace,M Pace,James P. Williams,John Thornhill,Elizabeth Hamlyn,J Meyerowitz,Chris Willberg,Kersten K. Koelsch,Nicola Robinson,Nicola Robinson,Helen Brown,Helen Brown,Martin Fisher,Sabine Kinloch,David A. Cooper,Mauro Schechter,Giuseppe Tambussi,Sarah Fidler,Abdel Babiker,Jonathan Weber,Anthony D. Kelleher,Rodney E. Phillips,Rodney E. Phillips,John Frater,John Frater +26 more
TL;DR: It is shown that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial).
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Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report
Ravindra K. Gupta,Dimitra Peppa,Dimitra Peppa,Alison L. Hill,Cristina Gálvez,Maria Salgado,M Pace,Laura E. McCoy,Sarah A. Griffith,John Thornhill,Aljawharah Alrubayyi,Laura E P Huyveneers,Eleni Nastouli,Eleni Nastouli,Paul Grant,Simon Edwards,Andrew J. Innes,Andrew J. Innes,John Frater,John Frater,Monique Nijhuis,A.M.J. Wensing,Javier Martinez-Picado,Javier Martinez-Picado,Eduardo Olavarria +24 more
TL;DR: The London patient has been in HIV-1 remission for 30 months with no detectable replication-competent virus in blood, CSF, intestinal tissue, or lymphoid tissue, and Mathematical modelling suggests that the probability of remission for life (cure) is 98% in the context of 80% donor chimerism in total HIV target cells and greater than 99% probability of relapse.
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Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial
Sarah Fidler,Wolfgang Stöhr,M Pace,Lucy Dorrell,Andrew M. L. Lever,Sarah Pett,S Kinloch-de Loes,Julie Fox,Amanda Clarke,Mark Nelson,John Thornhill,Maryam Khan,Axel Fun,Mikaila Bandara,D Kelly,Jakub Kopycinski,Tomáš Hanke,Hongbing Yang,R. L. H. Bennett,Margaret Johnson,B Howell,Richard J. O. Barnard,Guoxin Wu,Steve Kaye,Mark R. Wills,Abdel Babiker,John Frater +26 more
TL;DR: This kick and kill approach conferred no significant benefit compared with ART alone on measures of the HIV reservoir, although this does not disprove the efficacyKick and kill strategy, for future trials enhancement of both kick and Kill agents will be required.
Journal ArticleDOI
Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection
John Thornhill,Jamie Inshaw,Soonita Oomeer,Pontiano Kaleebu,David A. Cooper,Gita Ramjee,Mauro Schechter,Giuseppe Tambussi,Julie Fox,José M. Miró,Jonathan Weber,Abdel Babiker,Kholoud Porter,Sarah Fidler +13 more
TL;DR: This study examined whether CD4/CD8 ratio similarly normalized in immediate vs. deferred ART at PHI and found that it was similar.