Jinshan Chen

TL;DR: A practical electrochemical oxidation of unactivated C–H bonds is presented, using a simple redox mediator, quinuclidine, with inexpensive carbon and nickel electrodes to selectively functionalize "deep-seated" methylene and methine moieties.

TL;DR: It is shown that within a Bruton’s tyrosine kinase/cereblon PROTAC system, potent knockdown correlates with alleviation of steric clashes in the absence of thermodynamic cooperativity, which broadens the scope of PROTAC applications and affects fundamental design criteria across the field.

TL;DR: The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions.

TL;DR: Reported here are procedures for a one-pot oxidation and rearrangement of propargylamines to synthesize enaminones, with supporting mechanistic studies.

TL;DR: In this paper, C-13 functionalized pleuromutilin intermediates were synthesized under mild conditions via C-H amidation chemistry and the highest yields were achieved using silver catalysis, resulting in stereoselective oxazolidinone formation.