Chao Wang

TL;DR: The importance of STAT3 as a potential target for cancer therapy is discussed and novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs are provided.

TL;DR: The common dysregulation of PI3K/Akt/mTOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment are reviewed and the recent developments in identification of predictive biomarkers are summarized.

TL;DR: This review provides a comprehensive overview of microRNAs with established functional relevance in breast cancer, their established target genes and resulting cellular phenotype, and the role and application of circulating miRNAs in breast cancers.

TL;DR: Next-generation sequencing data obtained from public portals and reviewing existing literature are analyzed to provide new insights on the potential of DEAD/H-box helicases to act as pharmacological drug targets in cancers and the potential small molecule inhibitors of helicases and their therapeutic value are discussed.

TL;DR: A brief summary of these miRNA-associated hallmarks in breast cancer progression and a highlight on a family of proteins known as DEAD-box RNA helicases, many of which have been found to be associated with mi RNA-associated tumorigenesis.