H
Henry Yang
Researcher at National University of Singapore
Publications - 160
Citations - 5710
Henry Yang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 39, co-authored 152 publications receiving 4371 citations. Previous affiliations of Henry Yang include University Health System & Singapore Immunology Network.
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Journal ArticleDOI
Correction: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
Boon Seng Soh,Shi-Yan Ng,Hao Wu,Kristina Buac,Joo-Hye C. Park,Xiaojun Lian,Jiejia Xu,Kylie S. Foo,Ulrika Felldin,Xiaobing He,Massimo Nichane,Henry Yang,Lie Bu,Ronald A. Li,Bing Lim,Kenneth R. Chien +15 more
TL;DR: This work aims to provide a forward-looking, scalable and scalable approach to regenerative medicine that can be integrated into the clinical practice and improve the quality and efficiency of existing treatments.
Journal ArticleDOI
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Vikas Madan,Deepika Kanojia,Jia Li,Ryoko Okamoto,Aiko Sato-Otsubo,Aiko Sato-Otsubo,Alexander Kohlmann,Masashi Sanada,Masashi Sanada,Vera Grossmann,Janani Sundaresan,Yuichi Shiraishi,Satoru Miyano,Felicitas Thol,Arnold Ganser,Henry Yang,Torsten Haferlach,Seishi Ogawa,Seishi Ogawa,H. Phillip Koeffler,H. Phillip Koeffler +20 more
TL;DR: A specific role for ZRSR2 in RNA splicing is identified and dysregulated splicing of U12-type introns is highlighted as a characteristic feature of Z RSR2 mutations in MDS.
Journal ArticleDOI
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse
Manoj Garg,Yasunobu Nagata,Deepika Kanojia,Anand Mayakonda,Kenichi Yoshida,Sreya Haridas Keloth,Zhi Jiang Zang,Yusuke Okuno,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Ling-Wen Ding,Tamara Alpermann,Qiao-Yang Sun,De-Chen Lin,Wenwen Chien,Vikas Madan,Li Zhen Liu,Kar Tong Tan,Abhishek Sampath,Subhashree Venkatesan,Koiti Inokuchi,Satoshi Wakita,Hiroki Yamaguchi,Wee Joo Chng,Shirley Kow Yin Kham,Allen Eng Juh Yeoh,Masashi Sanada,Joanna Schiller,Karl Anton Kreuzer,Steven M. Kornblau,Hagop M. Kantarjian,Torsten Haferlach,Michael Lill,Ming Chung Kuo,Lee Yung Shih,Igor Wolfgang Blau,Olga Blau,Henry Yang,Seishi Ogawa,H. Phillip Koeffler,H. Phillip Koeffler +42 more
TL;DR: This study clearly shows that FLT3-ITD AML requires additional driver genetic alterations in addition to FLT2-ITd alone, and DNMT3A mutations are the most stable mutations.
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Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma
Yan-Yi Jiang,De-Chen Lin,De-Chen Lin,Anand Mayakonda,Masaharu Hazawa,Ling-Wen Ding,Wenwen Chien,Liang Xu,Ye Chen,Jin Fen Xiao,William Senapedis,Erkan Baloglu,Deepika Kanojia,Li Shang,Xin Xu,Henry Yang,Jeffrey W. Tyner,Ming Rong Wang,H. Phillip Koeffler,H. Phillip Koeffler +19 more
TL;DR: Integrative approaches led to a catalogue of SE-associated master regulators and oncogenic transcripts, which may significantly promote both the understanding of OSCC biology and the development of more innovative therapies.
Journal ArticleDOI
Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression.
Wen Cai Zhang,Tan Min Chin,Henry Yang,Min En Nga,Declan Patrick Lunny,Edwin Kok Hao Lim,Li Li Sun,Yin Huei Pang,Yi Ning Leow,Shanneen Rossellini Y Malusay,Priscilla Xin Hui Lim,Jeravan Zili Lee,Benedict Jian Wei Tan,Ng Shyh-Chang,Elaine Hsuen Lim,Wan-Teck Lim,Daniel Shao Weng Tan,Eng Huat Tan,Bee Choo Tai,Ross A. Soo,Wai Leong Tam,Wai Leong Tam,Bing Lim +22 more
TL;DR: Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft tumours, thus indicating that these miRNAs are clinically useful as biomarkers for tracking disease progression and as therapeutic targets.