C
Charalambos C. Solomides
Researcher at Thomas Jefferson University
Publications - 102
Citations - 3467
Charalambos C. Solomides is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Lung injury & Lung cancer. The author has an hindex of 33, co-authored 98 publications receiving 3027 citations. Previous affiliations of Charalambos C. Solomides include Thomas Jefferson University Hospital & Temple University.
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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.
Liang-Chuan S. Wang,Albert C. Lo,John Scholler,Jing Sun,Rajrupa S. Majumdar,Veena Kapoor,Michael Antzis,Cody E. Cotner,Laura A. Johnson,Amy C. Durham,Charalambos C. Solomides,Carl H. June,Ellen Puré,Steven M. Albelda +13 more
TL;DR: It is shown that inhibiting tumor growth by targeting tumor stroma with adoptively transferred CAR T cells directed to FAP can be safe and effective, suggesting that further clinical development of anti-human FAP-CAR is warranted.
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MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation.
Pan Li,Ni Zhu,Bing Yi,Nadan Wang,Ming Chen,Xiaohua You,Xianxian Zhao,Charalambos C. Solomides,Yong-Wen Qin,Jianxin Sun +9 more
TL;DR: The results indicate that miR-663 is a novel modulator of human VSMC phenotypic switch by targeting JunB/myosin light chain 9 expression, and suggest that targeting miD-663 or its specific downstream targets in humanVSMCs may represent an attractive approach for the treatment of proliferative vascular diseases.
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Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury
Benjamin D. Kozower,Melpo Christofidou-Solomidou,Thomas D. Sweitzer,Silvia Muro,Donald G. Buerk,Charalambos C. Solomides,Steven M. Albelda,G. Alexander Patterson,Vladimir R. Muzykantov +8 more
TL;DR: Findings validate the therapeutic potential of vascular immunotargeting as a drug delivery strategy to reduce endothelial injury and potential applications of this strategy include improving the outcome of clinical lung transplantation and treating a wide variety of endothelial disorders.
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Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.
James C. Lee,Paul Kinniry,Evguenia Arguiri,Matthew Serota,Stathis Kanterakis,Shampa Chatterjee,Charalambos C. Solomides,Prashanthi Javvadi,Constantinos Koumenis,Keith A. Cengel,Melpo Christofidou-Solomidou +10 more
TL;DR: Dietary curcumin ameliorates radiation-induced pulmonary fibrosis and increases mouse survival while not impairing tumor cell killing by radiation.
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Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling
Renato V. Iozzo,Simone Buraschi,Marco Genua,Shi Qiong Xu,Charalambos C. Solomides,Stephen C. Peiper,Leonard G. Gomella,Rick C. Owens,Andrea Morrione +8 more
TL;DR: It is shown that the expression of decorin is inversely correlated with IGF-IR expression in low and high grade bladder cancers and this provides a novel mechanism for decorin in negatively modulating both IGF-I and its receptor.