C
Charles C. Kim
Researcher at University of California, San Francisco
Publications - 71
Citations - 5830
Charles C. Kim is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immune system & Immunity. The author has an hindex of 37, co-authored 70 publications receiving 4974 citations. Previous affiliations of Charles C. Kim include University of Illinois at Urbana–Champaign & University of Melbourne.
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Journal ArticleDOI
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.
Hansen Lui,Jiasheng Zhang,Stefanie Ritter Makinson,Michelle K. Cahill,Kevin W. Kelley,Hsin-Yi Huang,Yulei Shang,Michael C. Oldham,Lauren Herl Martens,Fuying Gao,Giovanni Coppola,Steven A. Sloan,Christine L. Hsieh,Charles C. Kim,Eileen H. Bigio,Sandra Weintraub,M.-Marsel Mesulam,Rosa Rademakers,Ian R. A. Mackenzie,William W. Seeley,Anna Karydas,Bruce L. Miller,Barbara Borroni,Roberta Ghidoni,Robert V. Farese,Jeanne T. Paz,Ben A. Barres,Eric J. Huang,Eric J. Huang +28 more
TL;DR: In this paper, the authors used transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-dependent, progressive upregulation of lysosomal and innate immunity genes, increased complement production, and enhanced synaptic pruning in microglia.
Journal ArticleDOI
Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse.
Trevor D. Lawley,Kaman Chan,Lucinda J. Thompson,Charles C. Kim,Gregory R. Govoni,Denise M. Monack +5 more
TL;DR: Data indicate that Salmonella long-term systemic infection in the mouse requires a diverse repertoire of virulence factors, and a progressive selection against serovar Typhimurium mutants based upon the duration of the infection is observed, suggesting that different classes of genes may be required at distinct stages of infection.
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Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.
Fei Chen,Wenhui Wu,Ariel Millman,Joshua F. Craft,Eunice Chen,Nirav Patel,Jean L Boucher,Joseph F. Urban,Charles C. Kim,William C. Gause +9 more
TL;DR: Differentially activated neutrophils in the context of a type 2 immune response therefore prime a long-lived effector macrophage phenotype that directly mediates rapid nematode damage and clearance.
Journal ArticleDOI
Molecular definition of the identity and activation of natural killer cells
Natalie A. Bezman,Charles C. Kim,Joseph C. Sun,Gundula Min-Oo,Deborah W. Hendricks,Yosuke Kamimura,J Adam Best,Ananda W. Goldrath,Lewis L. Lanier +8 more
TL;DR: Using whole-genome microarray data sets of the Immunological Genome Project, the authors demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions.
Journal ArticleDOI
Genomic Comparison of Salmonella enterica Serovars and Salmonella bongori by Use of an S. enterica Serovar Typhimurium DNA Microarray
TL;DR: It is shown that the taxonomic organization of Salmonella into serogroups provides a good first approximation of genetic relatedness, but does not account for genomic changes that contribute to a serovar's degree of host adaptation.