S
Stephen Baker
Researcher at University of Cambridge
Publications - 468
Citations - 29359
Stephen Baker is an academic researcher from University of Cambridge. The author has contributed to research in topics: Salmonella typhi & Typhoid fever. The author has an hindex of 68, co-authored 441 publications receiving 21731 citations. Previous affiliations of Stephen Baker include Wellcome Trust & International Vaccine Institute.
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Journal ArticleDOI
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Christopher J L Murray,Kevin S Ikuta,Fablina Sharara,Lucien Swetschinski,Gisela Robles Aguilar,Authia Gray,Chieh Fei Han,Catherine Bisignano,Puja C Rao,Eve E. Wool,Sarah Charlotte Johnson,Annie J. Browne,Michael G. Chipeta,Frederick Fell,Sean Hackett,Georgina Haines-Woodhouse,Bahar H. Kashef Hamadani,Emmanuelle A. P. Kumaran,Barney McManigal,Sureeruk Achalapong,Ramesh Agarwal,Samuel Akech,Samuel B. Albertson,John H Amuasi,Jason R. Andrews,Aleskandr Aravkin,Elizabeth A. Ashley,François-Xavier Babin,Freddie Bailey,Stephen Baker,Buddha Basnyat,Adrie Bekker,Rose G Bender,James A. Berkley,Adhisivam Bethou,Julia Bielicki,Suppawat Boonkasidecha,James Bukosia,Cristina Gardony Carvalheiro,Carlos A Castañeda-Orjuela,Vilada Chansamouth,Suman Chaurasia,Sara Chiurchiù,Fazle Rabbi Chowdhury,Rafai Clotaire Donatien,Aislinn Cook,Ben S. Cooper,Tim R. Cressey,Elia Criollo-Mora,Matthew Cunningham,Saffiatou Darboe,Nicholas P. J. Day,Maia De Luca,Klara Dokova,Angela Dramowski,Susanna Dunachie,Thuy Duong Bich,Tim Eckmanns,Daniel Eibach,Amir Emami,Nicholas A. Feasey,Natasha Fisher-Pearson,Karen Forrest,Coralith Garcia,Denise O Garrett,Petra Gastmeier,Ababi Zergaw Giref,Rachel C Greer,Vikas Gupta,Sebastian Haller,Andrea Haselbeck,Simon I. Hay,M. Holm,Susan Hopkins,Yingfen Hsia,Kenneth Iregbu,Jan Jacobs,Daniel Jarovsky,Fatemeh Javanmardi,Adam Jenney,Meera Khorana,Suwimon Khusuwan,Niranjan Kissoon,Elsa Kobeissi,Tomislav Kostyanev,Fiorella Krapp,Ralf Krumkamp,Ajay Kumar,Hmwe H Kyu,Cherry Lim,Kruy Lim,Direk Limmathurotsakul,Michael J. Loftus,Miles Lunn,Jianing Ma,Anand Manoharan,Florian Marks,Jürgen May,Mayfong Mayxay,Neema Mturi,Tatiana Múnera-Huertas,Patrick Musicha,Lilian Musila,Marisa Márcia Mussi-Pinhata,Ravi Naidu,Tomoka Nakamura,Ruchi Nanavati,Sushma Nangia,Paul N. Newton,Chanpheaktra Ngoun,Amanda Novotney,Davis Nwakanma,Christina W. Obiero,Theresa J. Ochoa,Antonio Olivas-Martinez,Piero Olliaro,Edna Ooko,Edgar Ortiz-Brizuela,Pradthana Ounchanum,Gi Deok Pak,Jose Luis Paredes,Anton Y. Peleg,Carlo Perrone,Thong Phe,Koukeo Phommasone,Nishad Plakkal,Alfredo Ponce-de-León,Mathieu Raad,Tanusha Ramdin,Sayaphet Rattanavong,Amy Riddell,Tamalee Roberts,Julie V. Robotham,Anna Roca,Victor D. Rosenthal,Kristina E. Rudd,Neal Russell,Helio S. Sader,Weerawut Saengchan,Janice W. Schnall,John Anthony G Scott,Samroeng Seekaew,Mike Sharland,Madhusudhan Shivamallappa,José Sifuentes-Osornio,A. John Simpson,Nicolas Steenkeste,Andrew J. Stewardson,Temenuga Stoeva,Nidanuch Tasak,Areerat Thaiprakong,Guy E. Thwaites,Caroline Tigoi,Claudia Turner,Paul Turner,H. Rogier van Doorn,Sithembiso Velaphi,Avina Vongpradith,Manivanh Vongsouvath,Huong X. Vu,Timothy R. Walsh,Judd L. Walson,Seymour Waner,Tri Wangrangsimakul,Prapass Wannapinij,Teresa M. Wozniak,Tracey E M W Young Sharma,Kalvin C. Yu,Peng Zheng,Benn Sartorius,Alan D. Lopez,Andy Stergachis,Catrin E. Moore,Christiane Dolecek,Mohsen Naghavi +174 more
TL;DR: This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.
Journal ArticleDOI
The genome sequence of Schizosaccharomyces pombe
Valerie Wood,R. Gwilliam,Marie-Adèle Rajandream,M. Lyne,Rachel Lyne,A. Stewart,J. Sgouros,N. Peat,Jacqueline Hayles,Stephen Baker,D. Basham,Sharen Bowman,Karen Brooks,D. Brown,Steve D.M. Brown,Tracey Chillingworth,Carol Churcher,Mark O. Collins,R. Connor,Ann Cronin,P. Davis,Theresa Feltwell,Andrew G. Fraser,S. Gentles,Arlette Goble,N. Hamlin,David Harris,J. Hidalgo,Geoffrey M. Hodgson,S. Holroyd,T. Hornsby,S. Howarth,Elizabeth J. Huckle,Sarah E. Hunt,Kay Jagels,Kylie R. James,L. Jones,Matthew Jones,S. Leather,S. McDonald,J. McLean,P. Mooney,Sharon Moule,Karen Mungall,Lee Murphy,D. Niblett,C. Odell,Karen Oliver,Susan O'Neil,D. Pearson,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Simon Rutter,David L. Saunders,Kathy Seeger,Sarah Sharp,Jason Skelton,Mark Simmonds,R. Squares,S. Squares,K. Stevens,K. Taylor,Ruth Taylor,Adrian Tivey,S. Walsh,T. Warren,S. Whitehead,John Woodward,Guido Volckaert,Rita Aert,Johan Robben,B. Grymonprez,I. Weltjens,E. Vanstreels,Michael A. Rieger,M. Schafer,S. Muller-Auer,C. Gabel,M. Fuchs,C. Fritzc,E. Holzer,D. Moestl,H. Hilbert,K. Borzym,I. Langer,Alfred Beck,Hans Lehrach,Richard Reinhardt,Thomas M. Pohl,P. Eger,Wolfgang Zimmermann,H. Wedler,R. Wambutt,Bénédicte Purnelle,André Goffeau,Edouard Cadieu,Stéphane Dréano,Stéphanie Gloux,Valerie Lelaure,Stéphanie Mottier,Francis Galibert,Stephen J. Aves,Z. Xiang,Cherryl Hunt,Karen Moore,S. M. Hurst,M. Lucas,M. Rochet,Claude Gaillardin,Victor A. Tallada,Victor A. Tallada,Andrés Garzón,Andrés Garzón,G. Thode,Rafael R. Daga,Rafael R. Daga,L. Cruzado,Juan Jimenez,Juan Jimenez,Miguel del Nogal Sánchez,F. del Rey,J. Benito,Angel Domínguez,José L. Revuelta,Sergio Moreno,John Armstrong,Susan L. Forsburg,L. Cerrutti,Todd M. Lowe,W. R. McCombie,Ian T. Paulsen,Judith A. Potashkin,G. V. Shpakovski,David W. Ussery,Bart Barrell,Paul Nurse +136 more
TL;DR: The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote, is sequenced and highly conserved genes important for eukARYotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing are identified.
Journal ArticleDOI
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Julian Parkhill,Gordon Dougan,Keith D. James,Nicholas R. Thomson,Derek Pickard,John Wain,Carol Churcher,Karen Mungall,Stephen D. Bentley,Matthew T. G. Holden,Mohammed Sebaihia,Stephen Baker,D. Basham,Karen Brooks,Tracey Chillingworth,Phillippa L. Connerton,A. Cronin,P. Davis,Robert L. Davies,L. Dowd,Nicholas J. White,Jeremy Farrar,Theresa Feltwell,N. Hamlin,Ashraful Haque,Tran Tinh Hien,S. Holroyd,Kay Jagels,Anders Krogh,Torben Larsen,S. Leather,Sharon Moule,Peadar O'Gaora,Christopher M. Parry,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +40 more
TL;DR: The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia,Brendan W. Wren,Peter Mullany,Neil F. Fairweather,Nigel P. Minton,Richard A. Stabler,Nicholas R. Thomson,Adam P. Roberts,Ana Cerdeño-Tárraga,Hongmei Wang,Matthew T. G. Holden,Anne Wright,Carol Churcher,Michael A. Quail,Stephen Baker,Nathalie Bason,Karen Brooks,Tracey Chillingworth,Ann Cronin,Paul Davis,Linda Dowd,Audrey Fraser,Theresa Feltwell,Zahra Hance,S. Holroyd,Kay Jagels,Sharon Moule,Karen Mungall,Claire Price,Ester Rabbinowitsch,Sarah Sharp,Mark Simmonds,K. Stevens,Louise Unwin,Sally Whithead,Bruno Dupuy,Gordon Dougan,Bart Barrell,Julian Parkhill +38 more
TL;DR: The complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain, is determined; it indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons.