C
Charles Dumontet
Researcher at Claude Bernard University Lyon 1
Publications - 174
Citations - 11171
Charles Dumontet is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Cancer & Nucleoside. The author has an hindex of 44, co-authored 174 publications receiving 10386 citations. Previous affiliations of Charles Dumontet include Lyon College & French Institute of Health and Medical Research.
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Journal ArticleDOI
Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet,Mary Ann Jordan +1 more
TL;DR: The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
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Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
Hervé Avet-Loiseau,Michel Attal,Philippe Moreau,Catherine Charbonnel,Frédéric Garban,Cyrille Hulin,Serge Leyvraz,Mauricette Michallet,Ibrahim Yakoub-Agha,Laurent Garderet,Gerald Marit,Lucienne Michaux,Laurent Voillat,Marc Renaud,Bernard Grosbois,Gaelle Guillerm,Lotfi Benboubker,Mathieu Monconduit,Catherine Thieblemont,Philippe Casassus,Denis Caillot,Anne-Marie Stoppa,Jean-Jacques Sotto,Marc Wetterwald,Charles Dumontet,Jean-Gabriel Fuzibet,Isabelle Azais,Véronique Dorvaux,Marc Zandecki,Régis Bataille,Stephane Minvielle,Jean-Luc Harousseau,Thierry Facon,Claire Mathiot +33 more
TL;DR: In myeloma, the genomic aberrations t(4;14) and del(17p), together with beta2-microglobulin level, are important independent predictors of survival and have implications for the design of risk-adapted treatment strategies.
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Maintenance therapy with thalidomide improves survival in patients with multiple myeloma
Michel Attal,Jean-Luc Harousseau,Serge Leyvraz,Chantal Doyen,Cyrille Hulin,Lofti Benboubker,Ibrahim Yakoub Agha,Jean-Henri Bourhis,Laurent Garderet,Brigitte Pegourie,Charles Dumontet,Marc Renaud,Laurent Voillat,Christian Berthou,Gerald Marit,Mathieu Monconduit,Denis Caillot,Bernard Grobois,Hervé Avet-Loiseau,Philippe Moreau,Thierry Facon +20 more
TL;DR: Thalidomide is an effective maintenance therapy in patients with multiple myeloma and maintenance treatment with pamidronate does not decrease the incidence of bone events.
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Nucleoside analogues and nucleobases in cancer treatment.
TL;DR: Greater understanding of the molecular mechanisms of anticancer nucleoside activity provides opportunities for potentiating their antitumour effects and strategies to optimise intracellular analogue accumulation and to enhance cancer-cell selectivity are proving beneficial in clinical trials.
Journal ArticleDOI
Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed
Catherine Thieblemont,Françoise Berger,Charles Dumontet,Isabelle Moullet,Fadhela Bouafia,Pascale Felman,Gilles Salles,Bertrand Coiffier +7 more
TL;DR: MALT lymphoma is an indolent disease but presents as a disseminated disease in one-third of the cases at diagnosis, and the dissemination does not change the outcome of the patients.