Charles E. Alpers

TL;DR: This work has shown that although light microscopy may appear similar in these entities, immunofluorescence findings with staining for immunoglobulin and complement and corresponding deposits by electron microscopy readily allow recognition of the immune complexes in MPGN.

TL;DR: The lesion known as fibrillary glomerulonephritis is characterized by the accumulation of fibrils that are roughly 10 to 20 nm in diameter and are throughout the mesangial matrix and basement membranes in a manner very similar to amyloid.

TL;DR: The dramatic immunosuppressive and nephrotoxic effects of CsA and tacrolimus are largely explained by their calcineurin inhibition.

TL;DR: Early transplant arteriopathy (ETA) as discussed by the authors is characterized by endothelial cell swelling and intimal edema but without the intimal arteritis that defines vascular rejection, which raises the specter of active rejection processes that require medical intervention.

TL;DR: The thymic stromal lymphopoietin transgenic mouse model of type III mixed cryoglobulinemia is used to test the importance of the inhibitory Fc receptor FcRllb in limiting the severity of disease expression, in demonstrating the deleterious effect of infiltrating monocyte/macrophage populations that is a characteristic feature of this type of glomerulonephritis, and in demonstrating its potential reversibility with appropriate therapeutic interventions.