Charles E. Alpers

TL;DR: Evidence is provided for glomerular capillary repair (angiogenesis) in the adult injured glomerulus, and glomeruli are capable of healing microaneurysms, and the mechanism involves basic fibroblast growth factor- and VPF/VEGF-mediated endothelial proliferative responses.

TL;DR: Wiskott-Aldrich syndrome protein (WASp) Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spontaneous revertant mutation, indicating that altered Treg fitness likely explains the autoimmune features in human WAS.

TL;DR: In patients with highly stenoticCarotid lesions who are undergoing carotid endarterectomy, gross plaque composition is similar regardless of preoperative symptom status, and it is unlikely that differences in the volume of intraplaque hemorrhage, lipid core, necrotic core, or calcification in atheroscleroticcarotid plaques explain their embolic history.

TL;DR: It is demonstrated that a population of interstitial cells with some muscle-like features can be identified in normal kidneys, including fibroblasts and not capillary endothelial cells or leukocytes.

TL;DR: It is demonstrated that osteopontin messenger RNA and protein levels are up-regulated in a proportion of proximal and distal tubules in three experimental models of glomerulonephritis, suggesting that osteobontin may be important for macrophage accumulation at specific sites in diseased tissue and may have a role in the pathogenesis of the tubulointerstitial injury that accompanies glomeral disease.