Charles E. Alpers

TL;DR: Lung cancers induced by J SRV infection in sheep and by JSRV Env expression in mice have similar histologic features and are primarily characterized by adenomatous proliferation of peripheral lung epithelial cells, so it is unnecessary to invoke a role for insertional mutagenesis, gene activation, viral replication, or expression of other viral gene products in sheep lung tumorigenesis.

TL;DR: It is proposed that together with its underlying Bowman's basement membrane, the TJ of PECs serve as a second barrier to protein when disturbed following PEC injury, and the increase in permeability of this layer to filtered protein is a mechanism underlying periglomerular inflammation characteristic of anti-GBM disease.

TL;DR: It is demonstrated that PDGF-D is a major mediator of mesangial cell proliferation and the importance of engagement of PDGF receptor-beta in transducing mesangia proliferative glomerulopathy is emphasized.

TL;DR: It is concluded that SAA is increased in the blood and produced in the kidneys of people with DKD and corresponding diabetic mouse models and is a compelling candidate for DKD therapeutic and biomarker discovery.

TL;DR: It is shown that superficial differentiated epithelial cells of the oral mucosa are the major cell type in which SFV replicates, which can explain the innocuous nature of SFV infection and the highly efficient transmission of FVs among NHPs.