C
Che-Hong Chen
Researcher at Stanford University
Publications - 89
Citations - 6702
Che-Hong Chen is an academic researcher from Stanford University. The author has contributed to research in topics: Aldehyde dehydrogenase & ALDH2. The author has an hindex of 33, co-authored 86 publications receiving 6052 citations. Previous affiliations of Che-Hong Chen include Veterans Health Administration.
Papers
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Journal ArticleDOI
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: a multi-omics analysis
Yu-Feng Hu,Yu-Feng Hu,Yu-Feng Hu,Chih Hsun Wu,Tsung Ching Lai,Yu Chan Chang,Ming-Jing Hwang,Ting Yung Chang,Ching Hui Weng,Peter Mu Hsin Chang,Che-Hong Chen,Daria Mochly-Rosen,Chi Ying F. Huang,Shih Ann Chen,Shih Ann Chen +14 more
TL;DR: In this article, the effect of ALDH2*2 mutation on atrial fibrillation susceptibility was evaluated using a multi-omics approach including whole-genome gene expression and proteomics analysis.
Journal ArticleDOI
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice.
Hsiao-Lin Lee,Siow-Wey Hee,Chin-Feng Hsuan,Wenjin Yang,Jing-Yong Huang,Ya-Ling Lin,Chih-Neng Hsu,Juey-Jen Hwang,Shiau-Mei Chen,Zhi-Zhong Ding,Tung-Yuan Lee,Yu-Chiao Lin,Feng-Chiao Tsai,Wei-Lun Su,Li-Yun Chueh,Meng-Lun Hsieh,Che-Hong Chen,Daria Mochly-Rosen,Yi-Cheng Chang,Yi-Cheng Chang,Lee-Ming Chuang +20 more
TL;DR: Wang et al. as discussed by the authors found that AD-9308, a water-soluble and highly selective ALDH2 activator, can improve LV diastolic and systolic functions, and wall remodeling in diabetic mice.
Journal ArticleDOI
The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice.
Andrey V. Malkovskiy,Lauren D. Van Wassenhove,Yury Goltsev,Kwame Osei-Sarfo,Che-Hong Chen,Bradley Efron,Lorraine J. Gudas,Daria Mochly-Rosen,Jayakumar Rajadas +8 more
TL;DR: This work conclusively demonstrates that that osteocytes in femurs of older female mice accumulate fat, and that fat accumulation is likely modulated by levels of acetaldehyde, the ethanol metabolite.
Journal ArticleDOI
The Role of Alcohol, LPS Toxicity, and ALDH2 in Dental Bony Defects.
TL;DR: In this paper, the authors examined the prospective association of ALDH2 activity with the proliferation and mineralization potential of human osteoblasts in vitro and found that the ALDH*2*2 mutation has a significant association with osteoporosis.
Patent
Aldehyde dehydrogenase-1 modulators and methods of use thereof
TL;DR: The present disclosure provides compounds that function as inhibitors of cytosolic aldehyde dehydrogenase-1 (ALDHlAl) activity as mentioned in this paper, which is a well-known enzyme inhibitor.