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Yury Goltsev
Researcher at Stanford University
Publications - 37
Citations - 2795
Yury Goltsev is an academic researcher from Stanford University. The author has contributed to research in topics: Tumor microenvironment & Medicine. The author has an hindex of 13, co-authored 32 publications receiving 1445 citations.
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Journal ArticleDOI
Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.
Yury Goltsev,Nikolay Samusik,Julia Kennedy-Darling,Salil S. Bhate,Matthew Hale,Gustavo Vazquez,Sarah Black,Garry P. Nolan +7 more
TL;DR: The fidelity of multiplexed spatial cytometry demonstrated here allows for quantitative systemic characterization of tissue architecture in normal and clinically aberrant samples.
Journal ArticleDOI
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front.
Christian M. Schürch,Salil S. Bhate,Graham L. Barlow,Darci J. Phillips,Luca Noti,Inti Zlobec,Pauline Chu,Sarah Black,Janos Demeter,David R. McIlwain,Shigemi Kinoshita,Nikolay Samusik,Yury Goltsev,Garry P. Nolan +13 more
TL;DR: This study provides a framework for interrogating how complex biological processes, such as antitumoral immunity, occur through concerted actions of cells and spatial domains in effective versus ineffective tumor control.
Journal ArticleDOI
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
Stephen T. Oh,Erin F. Simonds,Carol D. Jones,Matthew Hale,Yury Goltsev,Kenneth D. Gibbs,Jason D. Merker,James L. Zehnder,Garry P. Nolan,Jason Gotlib +9 more
TL;DR: First human disease-related mutations in the adaptor protein LNK, a negative regulator of JAK-STAT signaling, in 2 patients with JAK2 V617F-negative myeloproliferative neoplasms are reported.
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A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry
TL;DR: Time-resolved progression analysis of the resulting data sets was used to construct a continuous molecular roadmap for three independent reprogramming systems, which varied substantially in Oct4, Sox2, Klf4, and c-Myc stoichiometry.
Journal ArticleDOI
SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Chien-Ting Wu,Peter V. Lidsky,Yinghong Xiao,Ivan T. Lee,Ran Cheng,Tsuguhisa Nakayama,Sizun Jiang,Janos Demeter,Romina J. Bevacqua,Charles A. Chang,Robert L. Whitener,Anna K. Stalder,Bokai Zhu,Han Chen,Yury Goltsev,Alexandar Tzankov,Jayakar V. Nayak,Garry P. Nolan,Matthias S. Matter,Raul Andino,Peter K. Jackson +20 more
TL;DR: In this paper, the SARS-CoV-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by NRP1 inhibition.