Che-Hong Chen

TL;DR: The results demonstrate a methodology for the introduction of peptides into neonatal cardiac myocytes that allows study of their actions without substantial compromises in cell integrity.

TL;DR: It is reported that ethanol preconditioning requires PKCvarepsilon, whereas direct activation of ALDH2 reduces infarct size in both wild type and PKCVarepsilus knockout hearts, suggesting that direct activated aldehyde dehydrogenase 2 may represent a method of harnessing the cardioprotective effect of ethanol without the side effects associated with alcohol consumption.

TL;DR: The data in rodent models suggest that the mitochondrial enzyme ALDH2 regulates nociception and could serve as a molecular target for pain control, with AL DH2 activators, such as Alda-1, as potential non-narcotic, cardiac-safe analgesics.

TL;DR: It is demonstrated that ALDH2 plays a crucial role in maintaining normal mitochondrial function to protect against neurotoxicity and that Alda-1 is effective in ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptotic pathway.

TL;DR: The discovery of a general class of ALDH inhibitors with a common mechanism of action is reported, and it is demonstrated that these inhibitors undergo an enzyme-mediated β-elimination reaction generating a vinyl ketone intermediate that covalently modifies the active site cysteine residue present in these enzymes.