C
Cheng Jiang
Researcher at Fudan University
Publications - 4
Citations - 80
Cheng Jiang is an academic researcher from Fudan University. The author has contributed to research in topics: Spect imaging & Amyloid precursor protein. The author has an hindex of 4, co-authored 4 publications receiving 68 citations.
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Journal ArticleDOI
In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease
Chun-Jen Chen,Kazunori Bando,Hiroki Ashino,Kazumi Taguchi,Hideaki Shiraishi,Keiji Shima,Osuke Fujimoto,Chiemi Kitamura,Satoshi Matsushima,Keisuke Uchida,Yuto Nakahara,Hiroyuki Kasahara,Takao Minamizawa,Cheng Jiang,Ming-Rong Zhang,Maiko Ono,Masaki Tokunaga,Tetsuya Suhara,Makoto Higuchi,Kazutaka Yamada,Bin Ji +20 more
TL;DR: In this article, the authors investigated the availability of radiolabeled DRM106 (123/125I-DRM106 [6-iodo-2-[4-(1H-3-pyrazolyl)phenyl]imidazo[1,2-a]pyridine]), a compound with sufficient affinity for the synthesis of human Aβ fibrils and satisfactory metabolic stability, as a SPECT ligand in living brains.
In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]pyridine Derivative DRM106 in Mouse Model of Alzheimer’s Disease
Chen Chun-Jen,Kazunori Bando,Hiroki Ashino,Kazumi Taguchi,Hideaki Shiraishi,Keiji Shima,Osuke Fujimoto,Chiemi Kitamura,Satoshi Matsushima,Keisuke Uchida,Yuto Nakahara,Hiroyuki Kasahara,Takao Minamizawa,Cheng Jiang,Zhang Ming-Rong,Maiko Ono,Masaki Tokunaga,Tetsuya Suhara,Makoto Higuchi,Kazutaka Yamada,Bin Ji +20 more
TL;DR: The high potential of 123I-DRM106 for amyloid imaging in preclinical and clinical application is demonstrated, and it might more preferentially detect dense-cored/neuritic amyloids deposition, which is expected to be closely associated with neuropathologic changes of AD.
Journal ArticleDOI
Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer’s disease
Chun-Jen Chen,Kazunori Bando,Hiroki Ashino,Kazumi Taguchi,Hideaki Shiraishi,Osuke Fujimoto,Chiemi Kitamura,Satoshi Matsushima,Masayuki Fujinaga,Ming-Rong Zhang,Hiroyuki Kasahara,Takao Minamizawa,Cheng Jiang,Maiko Ono,Makoto Higuchi,Tetsuya Suhara,Kazutaka Yamada,Bin Ji +17 more
TL;DR: The results strongly suggested that compound DRM106 can be used as an imaging agent for SPECT to detect Aβ deposition in AD brain.
Journal ArticleDOI
Biological evaluation of the radioiodinated imidazo[1,2-a]pyridine derivative DRK092 for amyloid-β imaging in mouse model of Alzheimer's disease.
Chun-Jen Chen,Kazunori Bando,Hiroki Ashino,Kazumi Taguchi,Hideaki Shiraishi,Keiji Shima,Osuke Fujimoto,Chiemi Kitamura,Yasuaki Morimoto,Hiroyuki Kasahara,Takao Minamizawa,Cheng Jiang,Ming-Rong Zhang,Tetsuya Suhara,Makoto Higuchi,Kazutaka Yamada,Bin Ji +16 more
TL;DR: The conclusion is drawn that radioiodinated DRK092 is a potential SPECT ligand for amyloid imaging in AD.