M
Maiko Ono
Researcher at National Institute of Radiological Sciences
Publications - 65
Citations - 2711
Maiko Ono is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Tauopathy & Medicine. The author has an hindex of 19, co-authored 53 publications receiving 2057 citations. Previous affiliations of Maiko Ono include Tohoku University.
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Journal ArticleDOI
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Masahiro Maruyama,Hitoshi Shimada,Tetsuya Suhara,Hitoshi Shinotoh,Bin Ji,Jun Maeda,Ming-Rong Zhang,John Q. Trojanowski,Virginia M.-Y. Lee,Maiko Ono,Kazuto Masamoto,Harumasa Takano,Naruhiko Sahara,Naruhiko Sahara,Nobuhisa Iwata,Nobuyuki Okamura,Shozo Furumoto,Yukitsuka Kudo,Qing Chang,Takaomi C. Saido,Akihiko Takashima,Jada Lewis,Ming Kuei Jang,Ichio Aoki,Hiroshi Ito,Makoto Higuchi +25 more
TL;DR: A class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benZothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders are developed.
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Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography
Jun Maeda,Bin Ji,Toshiaki Irie,Takami Tomiyama,Masahiro Maruyama,Takashi Okauchi,Matthias Staufenbiel,Nobuhisa Iwata,Maiko Ono,Takaomi C. Saido,Kazutoshi Suzuki,Hiroshi Mori,Makoto Higuchi,Tetsuya Suhara +13 more
TL;DR: The results support the usefulness of the small animal-dedicated PET system in conjunction with high-specific radioactivity probes and appropriate Tg models not only for clarifying the mechanistic properties of amyloidogenesis in mouse models but also for preclinical tests of emerging diagnostic and therapeutic approaches to AD.
Journal ArticleDOI
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Bin Ji,Jun Maeda,Makoto Sawada,Maiko Ono,Takashi Okauchi,Motoki Inaji,Ming-Rong Zhang,Kazutoshi Suzuki,Kiyoshi Ando,Matthias Staufenbiel,John Q. Trojanowski,Virginia M.-Y. Lee,Makoto Higuchi,Tetsuya Suhara +13 more
TL;DR: Together, PBR expressions in astrocytes and microglia reflect beneficial and deleterious glial reactions, respectively, in diverse neurodegenerative disorders including AD, pointing to new applications of PBR imaging for monitoring the impact of gliosis on the pathogenesis and treatment of AD.
Journal ArticleDOI
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
Maiko Ono,Maiko Ono,Naruhiko Sahara,Katsushi Kumata,Bin Ji,Ruiqing Ni,Shunsuke Koga,Dennis W. Dickson,John Q. Trojanowski,Virginia M.-Y. Lee,Mari Yoshida,Isao Hozumi,Yasumasa Yoshiyama,John C. van Swieten,Agneta Nordberg,Tetsuya Suhara,Ming-Rong Zhang,Makoto Higuchi +17 more
TL;DR: Compared binding of tau positron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate binding assays with homologous and heterologous blockades using tauopathy brain samples indicate distinct selectivity of P BB3 compared to AV- 1451 for diverse tau fibril strains.
Journal ArticleDOI
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Yuji Nagai,Naohisa Miyakawa,Hiroyuki Takuwa,Yukiko Hori,Kei Oyama,Bin Ji,Manami Takahashi,Xi Ping Huang,Samuel T. Slocum,Jeffrey F. DiBerto,Yan Xiong,Takuya Urushihata,Toshiyuki Hirabayashi,Atsushi Fujimoto,Koki Mimura,Justin G. English,Jing Liu,Ken-ichi Inoue,Ken-ichi Inoue,Katsushi Kumata,Chie Seki,Maiko Ono,Masafumi Shimojo,Ming-Rong Zhang,Yutaka Tomita,Jin Nakahara,Tetsuya Suhara,Masahiko Takada,Makoto Higuchi,Jian Jin,Bryan L. Roth,Takafumi Minamimoto +31 more
TL;DR: DCZ represents a potent, selective, metabolically stable and fast-acting DREADD agonist with utility in both mice and nonhuman primates for a variety of applications.