M
Masaki Tokunaga
Researcher at National Institute of Radiological Sciences
Publications - 29
Citations - 546
Masaki Tokunaga is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Radioligand & AMPA receptor. The author has an hindex of 15, co-authored 29 publications receiving 439 citations.
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Journal ArticleDOI
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510.
Ai Ishikawa,Masaki Tokunaga,Jun Maeda,Takeharu Minamihisamatsu,Masafumi Shimojo,Hiroyuki Takuwa,Maiko Ono,Ruiqing Ni,Shigeki Hirano,Satoshi Kuwabara,Bin Ji,Ming-Rong Zhang,Ichio Aoki,Tetsuya Suhara,Makoto Higuchi,Naruhiko Sahara +15 more
TL;DR: The time-course of the [11C]PBB3- and TSPO-PET finding suggests that tau deposition triggers progressive neuroinflammation, and the sequential changes can be evaluated in vivo in mouse brains.
Journal ArticleDOI
Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System
Masaki Tokunaga,Nicholas Seneca,Ryong-Moon Shin,Jun Maeda,Shigeru Obayashi,Takashi Okauchi,Yuji Nagai,Ming-Rong Zhang,Ryuji Nakao,Hiroshi Ito,Robert B. Innis,Christer Halldin,Kazutoshi Suzuki,Makoto Higuchi,Tetsuya Suhara +14 more
TL;DR: The pharmacological reversal of methamphetamine-stimulated dopaminergic overflow by suppression of group I metabotropic glutamate (mGlu) receptor in living primates and rodents is demonstrated and insights on dopamine–glutamate cross talk are extended from extrastriatal localization of responsible mGlu receptors to intrastRIatal synergy.
Journal ArticleDOI
Visualization of AMPA Receptors in Living Human Brain With Positron Emission Tomography
Tomoyuki Miyazaki,Waki Nakajima,Mai Hatano,Yusuke Shibata,Yoko Kuroki,Tetsu Arisawa,Asami Serizawa,Akane Sano,Sayaka Kogami,Tomomi Yamanoue,Kimito Kimura,Yushi Hirata,Yuuki Takada,Yoshinobu Ishiwata,Masaki Sonoda,Masaki Tokunaga,Chie Seki,Yuji Nagai,Takafumi Minamimoto,Kazunori Kawamura,Ming-Rong Zhang,Naoki Ikegaya,Masaki Iwasaki,Naoto Kunii,Yuichi Kimura,Fumio Yamashita,Masataka Taguri,Hideaki Tani,Nobuhiro Nagai,Teruki Koizumi,Shinichiro Nakajima,Masaru Mimura,Michisuke Yuzaki,Hiroki Kato,Makoto Higuchi,Hiroyuki Uchida,Takuya Takahashi +36 more
TL;DR: A newly developed PET tracer allows visualization of AMPA receptors in the living human brain, providing a new tool to study their potential involvement in neurological or psychiatric disorders.
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Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Masafumi Shimojo,Hiroyuki Takuwa,Yuhei Takado,Masaki Tokunaga,Satoshi Tsukamoto,Keiichiro Minatohara,Maiko Ono,Chie Seki,Jun Maeda,Takuya Urushihata,Takeharu Minamihisamatsu,Ichio Aoki,Kazunori Kawamura,Ming-Rong Zhang,Tetsuya Suhara,Naruhiko Sahara,Makoto Higuchi +16 more
TL;DR: The findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegnerative tauopathies.
Journal ArticleDOI
Quantification of central substance P receptor occupancy by aprepitant using small animal positron emission tomography.
Tadashi Endo,Takeaki Saijo,Eisuke Haneda,Jun Maeda,Masaki Tokunaga,Ming-Rong Zhang,Ayako Kannami,Hidetoshi Asai,Masayuki Suzuki,Tetsuya Suhara,Makoto Higuchi +10 more
TL;DR: Findings support the utility of small animals and quantitative PET in the development of drugs targeting NK-1 receptors and the validity of this in vivo imaging system for preclinical characterization of candidate agents acting on NK- 1 receptors.