C
Cheng Shen
Researcher at Australian National University
Publications - 8
Citations - 123
Cheng Shen is an academic researcher from Australian National University. The author has contributed to research in topics: Inflammasome & Medicine. The author has an hindex of 3, co-authored 3 publications receiving 24 citations.
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Journal ArticleDOI
Cell biology of inflammasome activation
TL;DR: In this article, the role of mammalian cell types and organellar architectures in executing inflammasome responses is highlighted, highlighting the role and importance of mammalian cells and their organellar structures in executing inflammatory and apoptotic responses.
Journal Article
Inflammasomes in Colitis and Colorectal Cancer: Mechanism of Action and Therapies.
TL;DR: A review of the key mechanisms by which inflammasome signaling modulate inflammation and tumor development in colitis and colitis-associated colorectal cancer and the importance of using more tightly regulated experimental approaches to examine the role of gut microbiota is speculated.
Journal ArticleDOI
Gasdermins deliver a deadly punch to cancer
TL;DR: It is demonstrated that controlled activation of pyroptosis in tumor cells can induce anti-tumor immunity against implantable tumors, an effect that can be enhanced by checkpoint blockade.
Journal ArticleDOI
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Shouya Feng,Daniel Enosi Tuipulotu,Abhimanu Pandey,Weidong Jing,Cheng Shen,Chinh Ngo,Melkamu B. Tessema,Fei Ju Li,Daniel Fox,Anukriti Mathur,Anyang Zhao,Runli Wang,Klaus Pfeffer,Daniel Degrandi,Masahiro Yamamoto,Patrick C. Reading,Gaetan Burgio,Si Ming Man +17 more
TL;DR: This article showed that mouse guanylate-binding proteins (GBP1 and GBP3) are specifically required for inflammasome activation during infection with the cytosolic bacterium Francisella novicida.
Journal ArticleDOI
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins
Weidong Jing,Jordan Lo Pilato,Callum Kay,Shouya Feng,Daniel Enosi Tuipulotu,Anukriti Mathur,Cheng Shen,Chinh Ngo,Anyang Zhao,Lisa A. Miosge,Sidra A Ali,Elizabeth E. Gardiner,Milena M. Awad,Dena Lyras,Avril A. B. Robertson,Nadeem O. Kaakoush,Si Ming Man +16 more
TL;DR: Jin et al. as mentioned in this paper demonstrate that α-toxin secreted by C. septicum binds to glycosylphosphatidylinositol (GPI)-anchored proteins on the host plasma membrane, oligomerizing and forming a membrane pore that is permissive to efflux of magnesium and potassium ions.