Cell biology of inflammasome activation
TLDR
In this article, the role of mammalian cell types and organellar architectures in executing inflammasome responses is highlighted, highlighting the role and importance of mammalian cells and their organellar structures in executing inflammatory and apoptotic responses.About:
This article is published in Trends in Cell Biology.The article was published on 2021-07-17 and is currently open access. It has received 62 citations till now. The article focuses on the topics: Inflammasome & Pyroptosis.read more
Citations
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Journal ArticleDOI
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome
Liang Kou,Xiaosa Chi,Yadi Sun,Chao Han,Fang Wan,Sijia Yin,Jiawei Wu,Yunna Li,Qiulu Zhou,Wenkai Zou,Nian Xiong,Jinsha Huang,Yun Xia,Tao Wang +13 more
TL;DR: In this paper , the role of the core clock protein Rev-erbα and the microglia-mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome in PD pathogenesis was explored.
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Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy
TL;DR: Identifying cell cycle independent vulnerabilities of cancer is critical for developing alternative strategies that can overcome therapeutic resistance.
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Walking down Skeletal Muscle Lane: From Inflammasome to Disease
Nicolas Dubuisson,Nicolas Dubuisson,Romain Versele,María América Davis López de Carrizosa,María América Davis López de Carrizosa,Camille M. Selvais,Sonia Brichard,Michel Abou-Samra +7 more
TL;DR: In this article, the authors present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the inflammasome in muscle disorders.
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Novel Insights Into the Interactions Between the Gut Microbiome, Inflammasomes, and Gasdermins During Colorectal Cancer
TL;DR: The existing literature supporting the importance of the inflammasome–microbiota axis, as well as the activation and function of GSDMs, are summarized to gain a better mechanistic understanding of CRC pathogenesis.
Journal ArticleDOI
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome
Liang Kou,Xiaosa Chi,Yadi Sun,Chao Han,Fang Wan,Sijia Yin,Jiawei Wu,Yunna Li,Qiulu Zhou,Wenkai Zou,Nian Xiong,Jinsha Huang,Yun Xia,Tao Wang +13 more
TL;DR: In this paper , the role of the core clock protein Rev-erbα and the microglia-mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome in PD pathogenesis was explored.
References
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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UniProt: the universal protein knowledgebase in 2021
Alex Bateman,Maria Jesus Martin,Sandra Orchard,Michele Magrane,Rahat Agivetova,Shadab Ahmad,Emanuele Alpi,Emily H Bowler-Barnett,Ramona Britto,Borisas Bursteinas,Hema Bye-A-Jee,Ray Coetzee,Austra Cukura,Alan Wilter Sousa da Silva,Paul Denny,Tunca Doğan,ThankGod Ebenezer,Jun Fan,Leyla Jael Garcia Castro,Penelope Garmiri,George Georghiou,Leonardo Gonzales,Emma Hatton-Ellis,Abdulrahman Hussein,Alexandr Ignatchenko,Giuseppe Insana,Rizwan Ishtiaq,Petteri Jokinen,Vishal Joshi,Dushyanth Jyothi,Antonia Lock,Rodrigo Lopez,Aurelien Luciani,Jie Luo,Yvonne Lussi,Alistair MacDougall,Fábio Madeira,Mahdi Mahmoudy,Manuela Menchi,Alok Mishra,Katie Moulang,Andrew Nightingale,Carla Susana Oliveira,Sangya Pundir,Guoying Qi,Shriya Raj,Daniel Rice,Milagros Rodriguez Lopez,Rabie Saidi,Joseph Sampson,Tony Sawford,Elena Speretta,Edward Turner,Nidhi Tyagi,Preethi Vasudev,Vladimir Volynkin,Kate Warner,Xavier Watkins,Rossana Zaru,Hermann Zellner,Alan Bridge,Sylvain Poux,Nicole Redaschi,Lucila Aimo,Ghislaine Argoud-Puy,Andrea H. Auchincloss,Kristian B. Axelsen,Parit Bansal,Delphine Baratin,Marie-Claude Blatter,Jerven Bolleman,Emmanuel Boutet,Lionel Breuza,Cristina Casals-Casas,Edouard de Castro,Kamal Chikh Echioukh,Elisabeth Coudert,Béatrice A. Cuche,M Doche,Dolnide Dornevil,Anne Estreicher,Maria Livia Famiglietti,Marc Feuermann,Elisabeth Gasteiger,Sebastien Gehant,Vivienne Baillie Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Nevila Hyka-Nouspikel,Florence Jungo,Guillaume Keller,Arnaud Kerhornou,Vicente Lara,Philippe Le Mercier,Damien Lieberherr,Thierry Lombardot,Xavier D. Martin,Patrick Masson,Anne Morgat,Teresa Batista Neto,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Lucille Pourcel,Monica Pozzato,Manuela Pruess,Catherine Rivoire,Christian J. A. Sigrist,K Sonesson,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Chuming Chen,Yongxing Chen,John S. Garavelli,Hongzhan Huang,Kati Laiho,Peter B. McGarvey,Darren A. Natale,Karen E. Ross,C. R. Vinayaka,Qinghua Wang,Yuqi Wang,Lai-Su L. Yeh,Jian Zhang,Patrick Ruch,Douglas Teodoro +132 more
TL;DR: The UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal and a credit-based publication submission interface was developed.
Journal ArticleDOI
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert,Virginie Pétrilli,Robin van Bruggen,Chad Steele,Brooke T. Mossman,Jürg Tschopp +5 more
TL;DR: It is shown that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1β secretion, and support its role as a major proinflammatory “danger” receptor in particulate matter–related pulmonary diseases.
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