Cheol-Su Kim

TL;DR: Results suggests that H MG-CoA reductase inhibitors induce lymphoma cells apoptosis by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG- coenzyme A reduct enzyme reaction including mevalonate, FPP and GGPP.

TL;DR: The results indicate that different sized and charged ZnO NPs would cause in vitro and in vivo immunotoxicity, of which nature is an immunosuppression.

TL;DR: Investigation of the toxic effect of 100 nm negatively or positively charged zinc oxide NPs administered by gavage in Sprague Dawley rats established a no observed adverse effect level, and identified target organ(s) to be the stomach, pancreas, eye, and prostate gland, to speculate that this inflammatory damage might result from continuous irritation caused by both test articles.

TL;DR: Interestingly, the small-sized and negatively charged SiO2 NPs showed the most potent in vivo immunotoxicity by way of suppressing the proliferation of lymphocytes, depressing the killing activity of NK cells, and decreasing proinflammatory cytokine production, thus leading to immunosuppression.

TL;DR: The results of this study indicate that the NOAEL forSiO2EN20(−) and SiO2 EN100(−), administered by gavage in Sprague-Dawley rats, would most likely be 2,000 mg/kg, and no target organ was identified in rats of either sex.