C
Cheol-Su Kim
Researcher at Yonsei University
Publications - 73
Citations - 910
Cheol-Su Kim is an academic researcher from Yonsei University. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 14, co-authored 57 publications receiving 652 citations. Previous affiliations of Cheol-Su Kim include Chungnam National University.
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Journal ArticleDOI
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway
Xu Feng Qi,Li Zheng,Kyu-Jae Lee,Dong Heui Kim,Cheol-Su Kim,Dong Qing Cai,Zhourui Wu,Qin Jw,Yu Yh,Soo Ki Kim +9 more
TL;DR: Results suggests that H MG-CoA reductase inhibitors induce lymphoma cells apoptosis by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG- coenzyme A reduct enzyme reaction including mevalonate, FPP and GGPP.
Journal ArticleDOI
Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge.
Cheol-Su Kim,Hai Duong Nguyen,Rosa Mistica C. Ignacio,Jae Hyun Kim,Hyeon Cheol Cho,Eun Ho Maeng,Yu Ri Kim,Meyoung Kon Kim,Bae Keun Park,Soo Ki Kim +9 more
TL;DR: The results indicate that different sized and charged ZnO NPs would cause in vitro and in vivo immunotoxicity, of which nature is an immunosuppression.
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Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats
Yu Ri Kim,Jong Il Park,Eun Jeong Lee,Sung Ha Park,Nak Won Seong,Jun Ho Kim,Geon Yong Kim,Eun Ho Meang,Jeong Sup Hong,Su Hyon Kim,Sang Bum Koh,Min Seok Kim,Cheol-Su Kim,Soo Ki Kim,Sang Wook Son,Young Rok Seo,Boo Hyon Kang,Beom Seok Han,Seong Soo A. An,Hyo In Yun,Meyoung Kon Kim +20 more
TL;DR: Investigation of the toxic effect of 100 nm negatively or positively charged zinc oxide NPs administered by gavage in Sprague Dawley rats established a no observed adverse effect level, and identified target organ(s) to be the stomach, pancreas, eye, and prostate gland, to speculate that this inflammatory damage might result from continuous irritation caused by both test articles.
Journal ArticleDOI
Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge
Jae Hyun Kim,Cheol-Su Kim,Rosa Mistica C. Ignacio,Dong Heui Kim,Ma Easter Joy Sajo,Eun Ho Maeng,Xu Feng Qi,Seong Eun Park,Yu Ri Kim,Meyoung Kon Kim,Kyu-Jae Lee,Soo Ki Kim +11 more
TL;DR: Interestingly, the small-sized and negatively charged SiO2 NPs showed the most potent in vivo immunotoxicity by way of suppressing the proliferation of lymphocytes, depressing the killing activity of NK cells, and decreasing proinflammatory cytokine production, thus leading to immunosuppression.
Journal ArticleDOI
Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats
Yu Ri Kim,Seung Young Lee,Eun Jeong Lee,Sung Ha Park,Nak Won Seong,Heung Sik Seo,Sung Sup Shin,Seon Ju Kim,Eun Ho Meang,Myeong Kyu Park,Min Seok Kim,Cheol-Su Kim,Soo Ki Kim,Sang Wook Son,Young Rok Seo,Boo Hyon Kang,Beom Seok Han,Seong Soo A. An,Beom Jun Lee,Meyoung Kon Kim +19 more
TL;DR: The results of this study indicate that the NOAEL forSiO2EN20(−) and SiO2 EN100(−), administered by gavage in Sprague-Dawley rats, would most likely be 2,000 mg/kg, and no target organ was identified in rats of either sex.