Cheryl Gillett

TL;DR: It is shown that in clinical material p27 expression is associated with proliferative activity and while univariate analysis shows it to be a significant indicator of prognosis, this significance is lost in multivariate analysis when traditional prognostic factors are included in the model.

TL;DR: It is shown that HxR9 causes apoptosis in a number of breast cancer-derived cell lines and that sensitivity to HXR9 is directly related to the averaged expression of HOX genes HOXB1 through to HOXb9, providing a potential biomarker to predict the sensitivity of breast tumors to H XR9 or its derivatives.

TL;DR: S100 immunoreactivity is not a reliable means of differentiating between luminal epithelial and myoepithelial cells, and the possibility that staining with antibody to S100 protein may be affected by methods of fixation and immunohistochemical technique is discussed.

TL;DR: HMLVs are integral members of the MMTV family; MMTVs/H MLVs are genetically distinct from HERVs; and MMTV/HMLV DNA is not present in human breast cancer cell lines or clinical biopsies in the authors' locality.

TL;DR: S-phase fraction was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR), and had independent prognostic significance when considering a range of other clinicopathological variables, namely tumour grade and stage, nodal status, patient age, tumour size, menstrual status and treatment details.