C
Chetan E. Chitnis
Researcher at Pasteur Institute
Publications - 187
Citations - 11450
Chetan E. Chitnis is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 54, co-authored 173 publications receiving 10535 citations. Previous affiliations of Chetan E. Chitnis include University of California, Berkeley & University of Valle.
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Journal ArticleDOI
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.
Joseph D. Smith,Chetan E. Chitnis,Alistar G. Craig,David J. Roberts,Diana E. Hudson-Taylor,David S. Peterson,Robert Pinches,Chris I. Newbold,Louis H. Miller +8 more
TL;DR: It is shown that expression of variant antigenic determinants is correlated with expression of individual members of a large, multigene family named var, which is consistent with the involvement of var genes in antigenic variation and binding to endothelium.
Journal ArticleDOI
A research agenda to underpin malaria eradication.
Pedro L. Alonso,Graham Brown,Myriam Arévalo-Herrera,Fred Binka,Chetan E. Chitnis,Frank H. Collins,Ogobara K. Doumbo,Brian Greenwood,B. Fenton Hall,Myron M. Levine,Kamini Mendis,Robert D. Newman,Christopher V. Plowe,Mario Henry Rodriguez,Robert E. Sinden,Laurence Slutsker,Marcel Tanner +16 more
TL;DR: The Malaria Eradication Research Agenda initiative and the set of articles published in this PLoS Medicine Supplement that distill the research questions key to malaria eradication are introduced.
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A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor
Richard Horuk,Chetan E. Chitnis,Walter C. Darbonne,Timothy J. Colby,Anne C Rybicki,Terence J. Hadley,Louis H. Miller +6 more
TL;DR: Evidence is indicated that the Duffy blood group antigen is the erythrocyte receptor for the chemokines interleukin-8 (IL-8) and melanoma growth stimulatory activity (MGSA) and the possibility of receptor blockade for anti-malarial therapy is suggested.
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Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum
TL;DR: The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of E BA-175 expressed on COS cells, and the identification of both the receptor and ligand domains may suggest rational designs for receptor blockade and vaccines.
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Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion
TL;DR: The binding domains of these malaria ligands represent potential vaccine candidates and targets for receptor-blockade therapy and indicate conservation of the domain for erythrocyte binding in evolutionarily distant malaria species.