Chi C. Wong

TL;DR: The function of the yeast SBDS ortholog Sdo1 is identified, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosome, a key step in 60S maturation and translational activation of ribosomes.

TL;DR: Cryo-EM structures of human SBDS and SBDS–EFL1 bound to Dictyostelium discoideum 60S ribosomal subunits with and without endogenous eIF 6 reveal the conserved mechanism of eIF6 release, which is corrupted in both inherited and sporadic leukemias.

TL;DR: Findings in Dictyostelium and SDS patient cells provide compelling support for the hypothesis that SDS is a ribosomopathy caused by corruption of an essential cytoplasmic step in 60S subunit maturation.

TL;DR: The results indicate that a nilotinib/MEK inhibitor combination may represent an effective therapy in BRAF/NRAS wild type melanoma patients.

TL;DR: POT1 variants are a minor contributor to melanoma burden in the general population, but should be screened in individuals with a strong family history of melanoma and/or multiple malignancies, and the role of variants in the regulation of telomere length and complex formation is defined through molecular dynamics simulations.