L
Louise M. Tonkin
Researcher at University of Cambridge
Publications - 5
Citations - 973
Louise M. Tonkin is an academic researcher from University of Cambridge. The author has contributed to research in topics: DNA ligase & DNA polymerase mu. The author has an hindex of 5, co-authored 5 publications receiving 922 citations. Previous affiliations of Louise M. Tonkin include University of Sussex & Laboratory of Molecular Biology.
Papers
More filters
Journal ArticleDOI
Identification of a DNA Nonhomologous End-Joining Complex in Bacteria
Geoffrey R. Weller,Boris Kysela,Rajat Roy,Louise M. Tonkin,Elizabeth Scanlan,Marina Della,Susanne Krogh Devine,Jonathan P. Day,Adam Wilkinson,Fabrizio d'Adda di Fagagna,Kevin M. Devine,Richard P. Bowater,Penny A. Jeggo,Stephen P. Jackson,Aidan J. Doherty +14 more
TL;DR: These data provide evidence that many bacteria possess a DNA DSB repair apparatus that shares many features with the NHEJ system of eukarya and suggest that this DNA repair pathway arose before the prokaryotic and eukaryotic lineages diverged.
Journal ArticleDOI
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.
Tobias F. Menne,Beatriz Goyenechea,Beatriz Goyenechea,Nuria Sánchez-Puig,Nuria Sánchez-Puig,Chi C. Wong,Chi C. Wong,Louise M. Tonkin,Louise M. Tonkin,Philip J Ancliff,Renee L. Brost,Michael Costanzo,Charles Boone,Alan J. Warren,Alan J. Warren +14 more
TL;DR: The function of the yeast SBDS ortholog Sdo1 is identified, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosome, a key step in 60S maturation and translational activation of ribosomes.
Journal ArticleDOI
Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Machine
Marina Della,Phillip L. Palmbos,Hui Min Tseng,Louise M. Tonkin,Louise M. Tonkin,James M. Daley,Leana M Topper,Robert S. Pitcher,Alan E. Tomkinson,Thomas E. Wilson,Aidan J. Doherty +10 more
TL;DR: It is demonstrated that prokaryotic Ku and ligase form a bona fide NHEJ system that encodes all the recognition, processing, and ligation activities required for DSB repair.
Journal ArticleDOI
Domain Structure of a NHEJ DNA Repair Ligase from Mycobacterium tuberculosis
TL;DR: DNA-binding assays revealed that both the polymerase and ligase domains bind DNA in vitro, the latter with considerably higher affinity, suggesting it may recruit Mt-Lig to Ku-bound DNA in vivo.
Journal ArticleDOI
Mycobacteriophage exploit NHEJ to facilitate genome circularization.
Robert S. Pitcher,Louise M. Tonkin,Louise M. Tonkin,James M. Daley,Phillip L. Palmbos,Andrew J. Green,Tricia L. Velting,Anna Brzostek,Małgorzata Korycka-Machała,Steve Cresawn,Jarosław Dziadek,Graham F. Hatfull,Thomas E. Wilson,Aidan J. Doherty +13 more
TL;DR: A new paradigm for sequestration of the host cell NHEJ process by bacteriophage is established and a framework for understanding similar transactions in eukaryotic viral infections is provided.