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Chi-Sang Poon
Researcher at Massachusetts Institute of Technology
Publications - 114
Citations - 2984
Chi-Sang Poon is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heart rate variability & Reflex. The author has an hindex of 30, co-authored 114 publications receiving 2813 citations. Previous affiliations of Chi-Sang Poon include University of New Hampshire & North Dakota State University.
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Journal ArticleDOI
DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
Guoping Fan,Caroline Beard,Richard Z. Chen,Györgyi Csankovszki,Yi Sun,Marina S. Siniaia,Detlev Biniszkiewicz,Brian Bates,Brian Bates,Peggy P. Lee,Peggy P. Lee,Ralf Kühn,Ralf Kühn,Andreas Trumpp,Chi-Sang Poon,Christopher B. Wilson,Rudolf Jaenisch +16 more
TL;DR: Dnmt1 deficiency in postmitotic neurons neither affected levels of global DNA methylation nor influenced cell survival during postnatal life, and hypomethylated CNS neurons were impaired functionally and were selected against at postnatal stages.
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A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity
TL;DR: A CMOS circuit implementation of a biophysically grounded neuromorphic (iono-neuromorphic) model of synaptic plasticity that is capable of capturing both the spike rate-dependent plasticity (SRDP, of the Bienenstock-Cooper-Munro or BCM type) and STDP rules is proposed.
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Internal models in sensorimotor integration: perspectives from adaptive control theory.
Chung Tin,Chi-Sang Poon +1 more
TL;DR: This interdisciplinary framework should facilitate the experimental elucidation of the mechanisms of internal models in sensorimotor systems and the reverse engineering of such neural mechanisms into novel brain-inspired adaptive control paradigms in future.
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Ventilatory control in hypercapnia and exercise: optimization hypothesis.
TL;DR: A model of the respiratory control system incorporating both chemical and respiratory neuromechanical feedbacks to describe the steady-state ventilatory responses to CO2 inhalation and exercise demonstrated the plausibility of the proposed optimization mechanism and suggested an important role for respiratory-mechanical factors in the control of VE.
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Chaotic Signatures of Heart Rate Variability and Its Power Spectrum in Health, Aging and Heart Failure
Guo-Qiang Wu,Natalia M. Arzeno,Linlin Shen,Dakan Tang,Da-an Zheng,Naiqing Zhao,Dwain L. Eckberg,Chi-Sang Poon +7 more
TL;DR: Noise titration of running short-segment Holter tachograms from healthy subjects revealed circadian-dependent heartbeat chaos that was linked to the HF component (respiratory sinus arrhythmia) and relative ‘HF chaos’ levels were similar in young and elderly subjects despite proportional age-related decreases in HF and LF power.