D
Detlev Biniszkiewicz
Researcher at Massachusetts Institute of Technology
Publications - 11
Citations - 3643
Detlev Biniszkiewicz is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 11, co-authored 11 publications receiving 3489 citations.
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Journal ArticleDOI
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
Bernard Ramsahoye,Detlev Biniszkiewicz,Frank Lyko,Victoria H. Clark,Adrian Bird,Rudolf Jaenisch +5 more
TL;DR: Analysis of genomic methylation in transgenic Drosophila expressing Dnmt3a reveals that DnMT3a is predominantly a CpG methylase but also is able to induce methylation at CpA and at CPT.
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Epigenetic Instability in ES Cells and Cloned Mice
David Humpherys,Kevin Eggan,Hidenori Akutsu,Konrad Hochedlinger,William M. Rideout,Detlev Biniszkiewicz,Ryuzo Yanagimachi,Rudolf Jaenisch +7 more
TL;DR: Examination of imprinted gene expression in both mice cloned by nuclear transfer and in the embryonic stem cell donor populations from which they were derived suggests that mammalian development may be rather tolerant to epigenetic aberrations of the genome.
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DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons
Kimberly D. Siegmund,Caroline M. Connor,Mihaela Campan,Tiffany I. Long,Daniel J. Weisenberger,Detlev Biniszkiewicz,Rudolf Jaenisch,Peter W. Laird,Schahram Akbarian +8 more
TL;DR: DNA methylation is dynamically regulated in the human cerebral cortex throughout the lifespan, involves differentiated neurons, and affects a substantial portion of genes predominantly by an age-related increase.
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DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
Guoping Fan,Caroline Beard,Richard Z. Chen,Györgyi Csankovszki,Yi Sun,Marina S. Siniaia,Detlev Biniszkiewicz,Brian Bates,Brian Bates,Peggy P. Lee,Peggy P. Lee,Ralf Kühn,Ralf Kühn,Andreas Trumpp,Chi-Sang Poon,Christopher B. Wilson,Rudolf Jaenisch +16 more
TL;DR: Dnmt1 deficiency in postmitotic neurons neither affected levels of global DNA methylation nor influenced cell survival during postnatal life, and hypomethylated CNS neurons were impaired functionally and were selected against at postnatal stages.
Journal ArticleDOI
Retroviral expression in embryonic stem cells and hematopoietic stem cells.
TL;DR: The development of a mouse stem cell virus (MSCV) long terminal repeat-based retroviral vector that is expressed in both embryonic stem (ES) cells and hematopoietic stem (HS) cells is reported, demonstrating that DNA methylation is involved in the maintenance of Retroviral repression.