G
Györgyi Csankovszki
Researcher at University of Michigan
Publications - 34
Citations - 2723
Györgyi Csankovszki is an academic researcher from University of Michigan. The author has contributed to research in topics: Dosage compensation & Dosage compensation complex. The author has an hindex of 18, co-authored 33 publications receiving 2514 citations. Previous affiliations of Györgyi Csankovszki include Massachusetts Institute of Technology.
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Journal ArticleDOI
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.
Laurie Jackson-Grusby,Caroline Beard,Richard Possemato,Matthew Tudor,Douglas Fambrough,Györgyi Csankovszki,Jessica Dausman,Peggy Lee,Christopher B. Wilson,Eric S. Lander,Rudolf Jaenisch +10 more
TL;DR: The results demonstrate that loss of Dnmt1 causes cell-type–specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
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Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation
TL;DR: Using a conditional mutant Xist allele, direct evidence is provided for that loss of Xist RNA destabilizes the inactive state in somatic cells, leading to an increased reactivation frequency of an X-linked GFP transgene and of the endogenous hypoxanthine phosphoribosyl transferase (Hprt) gene in mouse embryonic fibroblasts.
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Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation.
TL;DR: Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation; however, this does not affect the ability of X to be reprogramed for inactivation.
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DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
Guoping Fan,Caroline Beard,Richard Z. Chen,Györgyi Csankovszki,Yi Sun,Marina S. Siniaia,Detlev Biniszkiewicz,Brian Bates,Brian Bates,Peggy P. Lee,Peggy P. Lee,Ralf Kühn,Ralf Kühn,Andreas Trumpp,Chi-Sang Poon,Christopher B. Wilson,Rudolf Jaenisch +16 more
TL;DR: Dnmt1 deficiency in postmitotic neurons neither affected levels of global DNA methylation nor influenced cell survival during postnatal life, and hypomethylated CNS neurons were impaired functionally and were selected against at postnatal stages.
Journal ArticleDOI
Three Distinct Condensin Complexes Control C. elegans Chromosome Dynamics
Györgyi Csankovszki,Karishma S. Collette,Karin Spahl,James F. Carey,Martha J. Snyder,Emily L. Petty,Uchita Patel,Tomoko M. Tabuchi,Hongbin Liu,Ian McLeod,James Thompson,Ali Sarkesik,John R. Yates,Barbara J Meyer,Kirsten A. Hagstrom +14 more
TL;DR: It is demonstrated that condensin subunits in C. elegans form three complexes, one that functions in dosage compensation and two that function in mitosis and meiosis, illustrating the versatility of condensins to function in both gene regulation and chromosome segregation.