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Chia-Yeh Lin
Researcher at Academia Sinica
Publications - 8
Citations - 118
Chia-Yeh Lin is an academic researcher from Academia Sinica. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 6, co-authored 7 publications receiving 104 citations. Previous affiliations of Chia-Yeh Lin include Fu Jen Catholic University.
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Journal ArticleDOI
H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast
Grace S. Shieh,Chin-Hua Pan,Jia-Hong Wu,Yun-Ju Sun,Chia-Chang Wang,Wei-Chun Hsiao,Chia-Yeh Lin,Luh Tung,Tien-Hsien Chang,Alastair B. Fleming,Cory Hillyer,Yi-Chen Lo,Shelley L. Berger,Mary Ann Osley,Cheng-Fu Kao +14 more
TL;DR: Evidence that H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae is provided and data suggest that H1N1 facilitates cross talk between chromatin and pre-mRNA splicing by modulating the distribution of intronic and exonic histone modifications.
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Heme oxygenase-1 induction by the ROS–JNK pathway plays a role in aluminum-induced anemia
TL;DR: Long-term exposure of Sprague-Dawley rats to Al decreased hemoglobin concentration and the hematocrit level, and the activity of aminolevulinic acid dehydratase in rat liver was reduced, but heme oxygenase (HO) activity was enhanced, suggesting an impairment of heme homeostasis.
Journal ArticleDOI
H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.
Chia-Yeh Lin,Meng-Ying Wu,Lisette Marjavaara,Mong Sing Lai,Wei-Chun Hsiao,Shih-Hsun Hung,Hsin-Yi Tseng,Duncan Edward Wright,Chen-Yi Wang,Guoo-Shyng W. Hsu,Didier Devys,Andrei Chabes,Cheng-Fu Kao +12 more
TL;DR: Results indicate that the regulation of H2B ubiquitylation is a key event in the maintenance of genome stability, through coordination of intra-S checkpoint activation, chromatin assembly and replication fork progression.
Journal ArticleDOI
Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MDA-MB-231 breast cancer cells
Chia-Yeh Lin,Chia-Yeh Lin,Wei-Chun Hsiao,Duncan Edward Wright,Chia-Ling Hsu,Yi-Chen Lo,Guoo-Shyng Wang Hsu,Cheng-Fu Kao +7 more
TL;DR: It is identified that the gene encoding the histone H2B ubiquitin ligase RNF20 (ring finger protein 20), a chromatin modifying enzyme and putative tumour suppressor, is up-regulated by resveratrol in MDA-MB-231 breast cancer cells.
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H2B ubiquitylation and the histone chaperone Asf1 cooperatively mediate the formation and maintenance of heterochromatin silencing.
TL;DR: It is found that transcriptional repression was slowly initiated and never fully established in mutants lacking both Asf1 and H2Bub, and the interplay between H2Hbub and Asf 1 may fine-tune nucleosome dynamics and SIR protein recruitment, and represent an ongoing requirement for proper formation and maintenance of heterochromatin.