Showing papers in "Journal of Inorganic Biochemistry in 2013"

TL;DR: UV study of the interaction of the complexes with calf-thymus DNA (CT DNA) has shown that the complexes can bind to CTDNA with [Cu(fluf)(bipy)Cl] exhibiting the highest binding constant to CT DNA.

TL;DR: The antibacterial test indicated that Ag NPs/HNTs showed good antibacterial performance against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus).

TL;DR: It can be concluded that the biological actions of NO are likely due primarily to its interactions with metal centers and reaction with radical species, and the likely biological targets for HNO are metal center and radical species (albeit with different chemistry compared to NO).

TL;DR: The results demonstrated that three Cu(II) complexes cause DNA damage that can induce the apoptosis of BEL-7402 cells.

TL;DR: The mechanism of action of these copper complexes on inhibiting tumor cell proteasome is identified and their great potential as novel anticancer agents is suggested.

TL;DR: DNA electrophoretic mobility experiments suggest that all complexes bind to linearized pDNA and supercoiled pDNA by intercalative manner resulting in catenanes formation as well as in double-stranded cleavage reflecting (or ending) in the formation of linear DNA.

TL;DR: The main research need is to investigate whether the concentrations of aluminium measured in the human breast can lead in vivo to any of the effects observed in cells in vitro and this would be aided by the identification of biomarkers specific for aluminium action.

TL;DR: Zinc(II) complexes of a non-steroidal anti-inflammatory drug, mefenamic acid(=Hmef) in the absence or presence of the nitrogen donor heterocyclic ligands 2,2'-bipyridine(=bipy) or 1,10-phenanthroline(=phen) have been synthesized and characterized, showing distinct binding modes of mefenamato carboxylato group.

TL;DR: DNA electrophoretic mobility experiments suggest that [Mn(erx)2(phen)] binds strongly to supercoiled pDNA and to linearized pDNA possibly by an intercalative manner provoking double-stranded cleavage reflecting in a nuclease-like activity.

TL;DR: Zn treatment has been found to improve carbohydrate and lipid metabolism in rodent models of diabetes, and in isolated cells, it enhances glucose transport, glycogen and lipid synthesis, and inhibits gluconeogenesis and lipolysis.

TL;DR: There is an unusual non-symmetrical coordination mode for the two functional groups: one acting as a thione and the second as a deprotonated thiolate in the cadmium complexes.

TL;DR: The (iso-)flavonoids chrysin 1, apigenin 2, genistein 3 and their homoleptic copper(II) complexes 4-6 were compared for general cancer cell growth inhibition and for antimetastatic effects on rapidly proliferating and metastasizing 518A2 melanoma cells as mentioned in this paper.

TL;DR: The interaction of V(iv)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V-O(2+) to hTF, as to whether the conformation of hTF upon binding to V( IV)O (2+) or to its complexes is changed.

TL;DR: Both sulfonate- and ester-functionalized silver(I) N-heterocyclic carbenes (NHCs) were evaluated for their antiproliferative activities in a wide panel of human cancer cells.

TL;DR: The cytotoxicity data suggest that [PdL(1)], [PLC(2)] and [PtL(2] may be endowed with important antitumor properties since they are capable of not only circumventing cisplatin resistance in A2780cisR cells but also exhibiting high antiproliferative activity in breast cancer MCF-7 cells.

TL;DR: It is suggested for the first time that endothelial cells that line the cerebral vasculature may have biochemical attributes conducive to binding and targeting aluminum to selective anatomical regions of the brain, such as the hippocampus, with potential downstream pro-inflammatory and pathogenic consequences.

TL;DR: The results suggest that opportunistic Pb(2+)-binding in Ca( 2+)/CaM has a profound impact on the conformation and dynamics of the essential molecular recognition sites of the central helix, and provides insight into the molecular toxicity of non-essential metal ions.

TL;DR: Formal redox potentials in aqueous solution were determined for copper(II) complexes with ligands having oxygen and nitrogen as donor atoms, so that a rough correlation between the measuredRedox potential and the typical geometrical arrangement of the copper( II) complex could be established.

TL;DR: This investigation shows that the application of QM/MM models to generate additional constraints to be used during NMR structural refinements represents an elegant approach to obtaining high-resolution NMR structures.

TL;DR: The current data implicate Al injected in early postnatal life in some CNS alterations that may be relevant for a better understanding of the aetiology of ASD.

TL;DR: Several chlorido and amino Pt2+ complexes of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich as mentioned in this paper exhibiting moderate to high cytotoxicity against cancer cell lines were studied in order to investigate the properties of DNA binding, in vitro DNA strand breaks, mechanism of topoisomerase (Topo I) inhibition and cellular increase in DNA accumulation.

TL;DR: The bifunctional Pt(IV) conjugate cis,cis,trans-diamminedichloridobis(valproato)platinum(IV), based on the cisplatin square-plane with two axial valproato (2-propylpentanoate, VPA) ligands, has been re-synthesized with a modified procedure and its biological activity was compared with that of its isomer n-octanoic acid

TL;DR: These stability constants indicate that Cu(I) forms strong complexes with thiols, they are not strong enough to effectively buffer Cu(i) in seawater, validating the method and assumptions.

TL;DR: The structure and function relationship of heme proteins in non-native states is thus as important as that in native states for elucidating the precise roles of heMe proteins in biological systems.

TL;DR: The ability of aluminium salts to increase migratory and invasive properties of MCF-7 cells suggests that the presence of aluminium in the human breast could influence metastatic processes, which is important because mortality from breast cancer arises mainly from tumour spread rather than from the existence of a primary tumour in the breast.

TL;DR: It is indicated that Al-induced growth stimulation might be due to alleviation of a latent Fe toxicity occurring in tea plants without Al supply, and supply of Al stimulated growth and reduced Fe uptake and transport.

TL;DR: Results suggest, for the first time, that an epigenetic mechanism involving an aluminum-triggered, NF-kB-sensitive, miRNA-34a-mediated down-regulation of TREM2 expression may impair phagocytic responses that ultimately contribute to Aβ42 peptide accumulation, aggregation, amyloidogenesis and inflammatory degeneration in the brain.

TL;DR: RuPMC was tested against human MCF7 and MDAMB231 breast and A2780 ovarian adenocarcinoma revealing IC50 values in the micromolar range, suggesting potential application of RuPMC as a new drug delivery system for Ru(II)Cp compounds.

TL;DR: The data suggest that the relevant species for biological activity are the [V(IV)O(L-2H)(NN)] compounds, their order of activity being dependent on the NN nature, but not much on the substitution on the salicylaldehyde semicarbazone moiety.

TL;DR: The physical properties of the previously reported fluorescent nitroxyl sensor, [Cu(BOT1)Cl]Cl are investigated and structural studies show that the BOT1 ligand can form Cu(II) coordination complexes of both square-pyramidal and trigonal-bipyramidal geometries.